AI Article Synopsis
- Two new flavonoids, sinoflavonoids NJ and NK, were discovered in the fruits of Royle, along with ten known compounds.
- Their chemical structures were analyzed using NMR spectroscopy and mass spectrometry.
- Sinoflavonoid NJ demonstrated significant anti-inflammatory effects, showing the highest inhibition of nitric oxide production in a mouse macrophage model with an IC value of 0.06 M.
Article Abstract
Two new prenylated flavonoids named sinoflavonoids NJ and NK (-), along with ten known compounds were isolated from the fruits of Royle. The chemical structures were determined through NMR spectroscopic data and MS analysis. Sinoflavonoid NJ () with an unusual 5,11-dioxabenzo[]fluoren-10-one skeleton was firstly reported from Berberidaceae. The isolated flavonoids were tested with LPS-induced RAW 264.7 mouse macrophages model for their anti-inflammatory activity. Sinoflavonoid NJ () showed the most potent inhibition on nitric oxide production with IC value as 0.06 M.
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| http://dx.doi.org/10.1080/14786419.2023.2188590 | DOI Listing |
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