AI Article Synopsis
- Plasmodium falciparum is the main malaria parasite in Nigeria, alongside minor cases of P. vivax, P. ovale, and P. malariae, with 6.6% and 1.4% of children infected by Pm and Po, respectively.
- A nationwide survey of 31,234 children aged 0-14 revealed a 34.2% seroprevalence for Pm, while Po and Pv had lower rates at 12.1% and no Pv cases detected.
- Wealthier households showed significant protection against Pm and Po infections, indicating socioeconomic factors influence malaria risk among Nigerian children.
Article Abstract
Plasmodium falciparum (Pf) is the dominant malaria parasite in Nigeria though P. vivax (Pv), P. ovale (Po), and P. malariae (Pm) are also endemic. Blood samples (n = 31,234) were collected from children aged 0-14 years during a 2018 nationwide HIV survey and assayed for Plasmodium antigenemia, Plasmodium DNA, and IgG against Plasmodium MSP1-19 antigens. Of all children, 6.6% were estimated to have Pm infection and 1.4% Po infection with no Pv infections detected. The highest household wealth quintile was strongly protective against infection with Pm (aOR: 0.11, 95% CI: 0.05-0.22) or Po (aOR= 0.01, 0.00-0.10). Overall Pm seroprevalence was 34.2% (95% CI: 33.3-35.2) with lower estimates for Po (12.1%, 11.6-12.5) and Pv (6.3%, 6.0-6.7). Pm seropositivity was detected throughout the country with several local government areas showing >50% seroprevalence. Serological and DNA indicators show widespread exposure of Nigerian children to Pm with lower rates to Po and Pv.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011577 | PMC |
| http://dx.doi.org/10.1038/s41467-023-37010-0 | DOI Listing |
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