Purpose: To describe the construction and testing of a portable point-of-care low-field MRI system on site in Africa.
Methods: All of the components to assemble a 50 mT Halbach magnet-based system, together with the necessary tools, were air-freighted from the Netherlands to Uganda. The construction steps included individual magnet sorting, filling of each ring of the magnet assembly, fine-tuning the inter-ring separations of the 23-ring magnet assembly, gradient coil construction, integration of gradient coils and magnet assembly, construction of the portable aluminum trolley and finally testing of the entire system with an open source MR spectrometer.
Results: With four instructors and six untrained personnel, the complete project from delivery to first image took approximately 11 days.
Conclusions: An important step in translating scientific developments in the western world from high-income industrialized countries to low- and middle-income countries (LMICs) is to produce technology that can be assembled and ultimately constructed locally. Local assembly and construction are associated with skill development, low costs and jobs. Point-of-care systems have a large potential to increase the accessibility and sustainability of MRI in LMICs, and this work demonstrates that technology and knowledge transfer can be performed relatively seamlessly.
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http://dx.doi.org/10.1002/nbm.4917 | DOI Listing |
Nat Commun
January 2025
Centre for Marine Magnetism (CM2, Department of Ocean Science and Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
Under sustained global warming, Arctic climate is projected to become more responsive to changes in North Pacific meridional heat transport as a result of teleconnections between low and high latitudes, but the underlying mechanisms remain poorly understood. Here, we reconstruct subarctic humidity changes over the past 400 kyr to investigate the role of low-to-high latitude interactions in regulating Arctic hydroclimate. Our reconstruction is based on precipitation-driven sediment input variations in the Subarctic North Pacific (SANP), which reveal a strong precessional cycle in subarctic humidity under the relatively low eccentricity variations that dominated the past four glacial-interglacial cycles.
View Article and Find Full Text PDFInt J Pharm
January 2025
The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi'an Jiaotong University, No.157 Xiwu Road, Xi'an, Shaanxi 710004, China. Electronic address:
Both photothermal therapy (PTT) and chemodynamic therapy (CDT) are designed to focus their antitumor effect on only the tumor site, thereby minimizing unwanted severe damage to healthy tissue outside the tumor. However, each monotherapy is limited in achieving complete tumor eradication, resulting in tumor recurrence. The combination of multiple therapies may help to overcome the limitations of single therapy, improve the chances of complete tumor eradication, and reduce the risk of recurrence.
View Article and Find Full Text PDFMed Phys
January 2025
Institute of Plasma Physics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.
Background: High-resolution brain imaging is crucial in clinical diagnosis and neuroscience, with ultra-high field strength MRI systems ( ) offering significant advantages for imaging neuronal microstructures. However, achieving magnetic field homogeneity is challenging due to engineering faults during the installation of superconducting strip windings and the primary magnet.
Purpose: This study aims to design and optimize active superconducting shim coils for a 7 T animal MRI system, focusing on the impact of safety margin, size, and adjustability of the second-order shim coils on the MRI system's optimization.
J Hazard Mater
January 2025
Huzhou Key Laboratory of Medical and Environmental Application Technologies, School of Life Sciences, Huzhou University, Zhejiang 313000, PR China; Zhejiang-French Digital Monitoring Laboratory for Aquatic Resources and Environment, Huzhou University, Huzhou 313000, PR China. Electronic address:
Mercury (II) ion (Hg) as highly toxic heavy metal may be accumulated in aquatic ecosystems and animals species so as to enter human body to conduct health harm. To ensure the safety of fishes food, hence, it is of great interest to evaluate the Hg levels in different kinds of fishes as well as Hg removal in aquaculture tailwater. In this article, a selective colormetric detection and efficient removal strategy has been developed for Hg ions by the controlled supermolecular self-assembly of melamine (MA)-platinum (Pt) composites onto mesoporous FeO carriers.
View Article and Find Full Text PDFACS Sens
January 2025
CAS Key Laboratory of Magnetic Materials and Devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, P. R. China.
Flexible pressure sensors are pivotal in advancing artificial intelligence, the Internet of Things (IoT), and wearable technologies. While microstructuring the functional layer of these sensors effectively enhances their performance, current fabrication methods often require complex equipment and time-consuming processes. Herein, we present a novel magnetization-induced self-assembly method to develop a magnetically grown microneedle array as a dielectric layer for flexible capacitive pressure sensors.
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