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| http://dx.doi.org/10.3803/EnM.2022.1643 | DOI Listing |
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Case report: Propylthiouracil-induced serious side effect: Perinuclear antineutrophil cytoplasmic antibody-associated vasculitis or IgA vasculitis?
Medicine (Baltimore)
July 2024
Department of Nephrology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China.
Article Synopsis
- Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare inflammatory disease linked to small blood vessels, often triggered by antithyroid drugs like propylthiouracil (PTU) in patients with Graves' disease.
- A case report of a female patient planning pregnancy highlighted the development of PTU-induced p-ANCA-associated vasculitis, leading to joint pain and kidney issues, evidenced by autoimmune markers.
- The patient was treated with glucocorticoids and immunosuppressive therapy, showing improvement in kidney and thyroid function, emphasizing the need for careful consideration of medication and pregnancy planning in similar cases.
Propylthiouracil (PTU) has been identified as a known cause of anti-neutrophil cytoplasmic antibodies-associated vasculitis. However, the association between PTU and immunoglobulin A (IgA) vasculitis remains uncertain due to its rarity and diverse clinical presentation. Here, we report the case of a 57-year-old female with a past medical history of chronic leukopenia and Graves' disease treated with PTU that presented with pancytopenia and widespread non-blanching ecchymoses on the bilateral legs.
View Article and Find Full Text PDFPropylthiouracil-Induced Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis Presenting with Multiple Sterile Abscesses, Mononeuritis Multiplex, and Splenic Vein Thrombosis: A Case Report and Literature Review.
Cureus
May 2024
Rheumatology, William Beaumont University Hospital, Royal Oak, USA.
Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) represents a rare group of disorders, that traditionally includes diseases like granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis (EGPA), and microscopic polyangiitis (MPA). However, AAV can also be triggered by medications such as propylthiouracil (PTU). This article focuses on the subset of drug-induced AAV.
View Article and Find Full Text PDFDiagnostic Dilemma of a Complex Case of Cerebral Vasculitis: A Rare Probable Drug-Induced Antineutrophil Cytoplasmic Antibody-Associated Vasculitis With Large Vessel Involvement.
Cureus
May 2024
Geriatrics and Stroke Medicine, Russells Hall Hospital, Dudley, GBR.
Article Synopsis
- A 43-year-old male with a history of Graves' disease developed neurological symptoms similar to a stroke, prompting an extensive evaluation for vasculitis and lymphoproliferative disease.
- Imaging revealed narrowing of the left middle cerebral artery, leading to a diagnosis of probable cerebral vasculitis and treatment with methylprednisolone and cyclophosphamide.
- Despite ongoing symptoms and further imaging showing additional narrowing, the treatment stabilized his condition, highlighting the diagnostic challenges of drug-induced ANCA-associated vasculitis.
Propylthiouracil-Induced Antineutrophil Cytoplasmic Antibody-Associated Vasculitis with Overlap IgA Nephropathy: A Case Report.
Case Rep Nephrol Dial
March 2024
Renal Unit, Bendigo Health, Bendigo, VIC, Australia.
Background: The anti-thyroid medication propylthiouracil (PTU) is a recognised cause of drug-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Pauci-immune crescentic glomerulonephritis is the characteristic feature of this condition on renal biopsy. We present a case of PTU-induced AAV with the unusual histological finding of overlap IgA nephropathy (IgAN) in a young female with treatment-resistant Graves' disease.
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