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Inflammation and immunomodulation in central nervous system injury - B cells as a novel therapeutic opportunity. | LitMetric

Inflammation and immunomodulation in central nervous system injury - B cells as a novel therapeutic opportunity.

Neurobiol Dis

Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Published: May 2023

AI Article Synopsis

  • Injuries to the central nervous system (like the brain and spine) are complicated and hard to treat because they cause inflammation that can harm the area even more.
  • After an injury, the body’s immune system gets confused and keeps causing more problems, leading to long-term damage.
  • Recent studies are looking at B lymphocytes (a type of immune cell) to see if they can help control inflammation and improve healing after these injuries.

Article Abstract

Acute injury to the central nervous system (CNS) remains a complex and challenging clinical need. CNS injury initiates a dynamic neuroinflammatory response, mediated by both resident and infiltrating immune cells. Following the primary injury, dysregulated inflammatory cascades have been implicated in sustaining a pro-inflammatory microenvironment, driving secondary neurodegeneration and the development of lasting neurological dysfunction. Due to the multifaceted nature of CNS injury, clinically effective therapies for conditions such as traumatic brain injury (TBI), spinal cord injury (SCI), and stroke have proven challenging to develop. No therapeutics that adequately address the chronic inflammatory component of secondary CNS injury are currently available. Recently, B lymphocytes have gained increasing appreciation for their role in maintaining immune homeostasis and regulating inflammatory responses in the context of tissue injury. Here we review the neuroinflammatory response to CNS injury with particular focus on the underexplored role of B cells and summarize recent results on the use of purified B lymphocytes as a novel immunomodulatory therapeutic for tissue injury, particularly in the CNS.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10758988PMC
http://dx.doi.org/10.1016/j.nbd.2023.106077DOI Listing

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