AI Article Synopsis
- Major depressive disorder (MDD) might increase the risk of getting Alzheimer's disease (AD).
- The study looked at people with different brain conditions to see how they did on tests and how their brain health related to MDD and other issues.
- Most people in the study had problems with their brain's white matter, which could make it harder to think clearly or feel happy.
Article Abstract
Major depressive disorder (MDD) is a risk factor for Alzheimer's disease (AD). Cerebrovascular disease (CVD) is implicated in MDD and AD. Our study compared participants with AD positive and negative cerebrospinal fluid (CSF) biomarkers on neuropsychological performance, remitted MDD status, and CVD burden. Next, we compared AD-CSF biomarkers and white matter hyperintensities (WMH) burden among three groups: mild cognitive impairment (MCI) (n = 12), MCI with remitted MDD (MDD+MCI) (n = 12), and remitted MDD alone (MDD) (n = 7). Few participants (18%) with MCI+MDD exhibited AD(+) biomarkers. Nearly all participants had moderate-severe WMH. WMH may contribute to cognitive impairment or depression in MCI patients with AD(-) biomarkers.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200207 | PMC |
| http://dx.doi.org/10.3233/JAD-221097 | DOI Listing |
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