Background: Granzyme B (GZMB) gene is related to human immunity and is considered as one of the genes indulged in vitiligo.
Objective: To evaluate the association between GZMB (R55Q) and (P94Q) gene polymorphisms with vitiligo development in a sample of vitiligo Egyptian patients.
Methods: This study was a case-control study which included 100 non-segmental vitiligo patients as well as a control group consisted of 100 healthy, sex and age matched vitiligo free individuals. The polymorphism of GZMB gene at (R55Q) and (P94A) were analyzed by polymerase chain reaction.
Results: P94Q and R55Q gene polymorphisms were significantly associated with higher VASI scores.
Conclusion: GZMB (Q55R) and P94A) gene polymorphisms are associated with the susceptibility to develop vitiligo in the Egyptian population and could help predicting more extensive forms of the disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005806 | PMC |
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