Resistance to nirmatrelvir (Paxlovid) has been shown by multiple groups and may already exist in clinical SARS-CoV-2 isolates. Here a panel of SARS-CoV-2 main protease (M) variants and a robust cell-based assay are used to compare the resistance profiles of nirmatrelvir, ensitrelvir, and FB2001. The results reveal distinct resistance mechanisms ("fingerprints") and indicate that these next-generation drugs have the potential to be effective against nirmatrelvir-resistant variants and .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002627 | PMC |
| http://dx.doi.org/10.1101/2023.02.25.530000 | DOI Listing |
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