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| http://dx.doi.org/10.4155/fdd-2022-0012 | DOI Listing |
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miRNA-205: a future therapeutic molecule for liver diseases.
Future Drug Discov
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Department of Immunology & Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
Circulating Serum miRNA-205 as a Diagnostic Biomarker for Ototoxicity in Mice Treated with Aminoglycoside Antibiotics.
Int J Mol Sci
September 2018
Laboratory of Smile Snail, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Korea.
Background: To confirm levels and detection timing of circulating microRNAs (miRNAs) in the serum of a mouse model for diagnosis of ototoxicity, circulating miR-205 in the serum was evaluated to reflect damages in the cochlear microstructure and compared to a kidney injury model.
Method: A microarray for miRNAs in the serum was performed to assess the ototoxic effects of kanamycin-furosemide. Changes in the levels for the selected miRNAs (miR-205, miR-183, and miR-103) were compared in the serum and microstructures of the cochlea (stria vascularis, organ of Corti, and modiolus) between the ototoxicity and normal mouse groups.
targets angiogenesis and EMT concurrently in anaplastic thyroid carcinoma.
Endocr Relat Cancer
March 2018
Cancer Molecular PathologySchool of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia
The current study aims to evaluate for the first time the inhibitory roles of in the pathogenesis of anaplastic thyroid carcinoma. In addition, we investigated the mechanisms by which miR-205 regulates angiogenesis and epithelial-to-mesenchymal transition (EMT) in cancer. Two anaplastic thyroid carcinoma cell lines were transfected with the expression vector pCMV- Selected markers of angiogenesis and EMT including vascular endothelial growth factor A () and zinc finger E-box-binding homeobox 1 () were investigated by Western blot.
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