The mediation pathology concept takes account to a large extent, though by no means exhaustively, of that horizontal language between peripheral cells, based on locally produced hormone-like substances and aimed at covering extremely short distances. This brings us well and truly into the paracrine domain of intercellular communication, whereby an exchange of messages takes place between adjacent cells via the interstitial spaces. Alongside this short-range communication network, there also exists a long-range network, involving above all the blood stream both as an intermediary and as mediation terrain. To the mediatory processes partakes the neuro-endocrine system, albeit it is not the predominant one as it was classically thought. There are other actors on the mediation stage: oxygen radical plays an important role.
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