3,4-methylenedioxymethamphetamine (MDMA), a recreational drug, induces euphoric sensations and psychosocial effects, such as increased sociability and empathy. Serotonin, also called 5-hydroxytryptamine (5-HT), is a neurotransmitter that has been associated with MDMA-induced prosocial effects. However, the detailed neural mechanisms remain elusive. In the present study, we investigated whether 5-HT neurotransmission in the medial prefrontal cortex (mPFC) and the basolateral nucleus of amygdala (BLA) is involved in MDMA-induced prosocial effects using the social approach test in male ICR mice. Systemic administration of (S)-citalopram, a selective 5-HT transporter inhibitor, before administration of MDMA failed to suppress MDMA-induced prosocial effects. On the other hand, systemic administration of the 5-HT receptor antagonist WAY100635, but not 5-HT, 5-HT, 5-HT, or 5-HT receptor antagonist, significantly suppressed MDMA-induced prosocial effects. Furthermore, local administration of WAY100635 into the BLA but not into the mPFC suppressed MDMA-induced prosocial effects. Consistent with this finding, intra-BLA MDMA administration significantly increased sociability. Together, these results suggest that MDMA induces prosocial effects through the stimulation of 5-HT receptors in the BLA.
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http://dx.doi.org/10.1016/j.ejphar.2023.175653 | DOI Listing |
Behav Sci (Basel)
January 2025
Department of Economics and Business, Faculty of Business and Communication Studies, University of Vic-Central University of Catalonia, 08500 Vic, Spain.
Ethical management is key to ensuring organizational sustainability, through resources such as autonomy or self-efficacy. However, economic and social uncertainty occasionally leads to adaptive responses that prioritize profit as the primary interest, blurring the integrating role of ethical leadership. There are a number of studies that support this reality in a virtual work environment.
View Article and Find Full Text PDFBehav Sci (Basel)
January 2025
Faculty of Humanities and Social Sciences, Macao Polytechnic University, Macao 999078, China.
It has been demonstrated that music can be an effective tool for shaping the future of college students. This study aimed to investigate the effects of college students' participation in group music activities on their pro-social behavior, and for the first time introduced the psychological variables of "positive social connections" and "perceived peer support". The results of this study show the following: (1) Group music activity participation is positively associated with pro-social behavior.
View Article and Find Full Text PDFFront Psychol
January 2025
Music College, Shanghai Normal University, Shanghai, China.
Introduction: The significance of music might be attributed to its role in social bonding, a function that has likely influenced the evolution of human musicality. Although there is substantial evidence for the relationship between prosocial songs and prosocial behavior, it remains unclear whether music alone, independent of lyrics, can influence prosocial behaviors. This study investigates whether music and the emotions it induces can influence prosocial decision-making, utilizing the classical two-dimensional model of emotion (mood and arousal).
View Article and Find Full Text PDFPsychol Res Behav Manag
January 2025
Department of General Education, Jiangxi Youth Vocational College, Nanchang, Jiangxi, People's Republic of China.
Background: The rapid growth of the global aging population highlights the need to address ageism and promote social inclusiveness. While considerable research has explored the impact of perceived ageism on older adults' mental health, limited attention has been given to how negative mental health factors-such as depression, anxiety, and stress (DAS)-influence ageist attitudes among younger populations, along with the psychological mechanisms underlying this relationship.
Purpose: This study first investigates the prevalence of ageism among undergraduates and its variation across certain socio-demographic factors at the research site.
Sci Adv
January 2025
Department of Pain Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Prosocial behaviors are advantageous to social species, but the neural mechanism(s) through which others receive benefit remain unknown. Here, we found that bystander mice display rescue-like behavior (tongue dragging) toward anesthetized cagemates and found that this tongue dragging promotes arousal from anesthesia through a direct tongue-brain circuit. We found that a direct circuit from the tongue → glutamatergic neurons in the mesencephalic trigeminal nucleus (MTN) → noradrenergic neurons in the locus coeruleus (LC) drives rapid arousal in the anesthetized mice that receive the rescue-like behavior from bystanders.
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