Background: Older drivers with mild cognitive impairment (MCI) often show declining driving performance. Evidence is lacking regarding whether their driving skills can be improved after practice.
Aims/objectives: To compare the practice effects of older drivers with MCI and drivers with normal cognition in an unfamiliar, standardized driving course with three practices.
Materials And Methods: Single-blind two-group observational design. Twelve drivers with confirmed MCI as the experimental group and ten with normal cognition (NC) as the control, all ≥ 55 years old. The primary outcome was to assess the practice effects, measured with an in-car global-positioning-system mobile application to compare the speed and directional control of a complex manoeuvre after practices. Secondary outcomes were to assess the pass/fail rate and mistakes observed for the 3/final on-road driving practice. No instructions were given during practice. Descriptive statistics and the Mann-Whitney U test were used for data analysis.
Results: No significant inter-group difference in the pass/fail rate and number of mistakes. Some MCI drivers performed better in the speed and directional control of the S-Bend manoeuvre after practices.
Conclusions: The driving performance of drivers with MCI may improve with practice.
Significance: Older drivers with MCI may potentially benefit from driver retraining.
Clinical Trial Registration: ClinicalTrials.gov (Identifier: NCT04648735).
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http://dx.doi.org/10.1080/11038128.2023.2184420 | DOI Listing |
Chin J Traumatol
January 2025
Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:
Purpose: Attention-deficit/hyperactivity disorder (ADHD) increases the risk of road traffic injuries through various mechanisms including higher risky driving behaviors. Therefore, drivers with ADHD are shown to be more prone to road traffic injuries. This study was conducted in a community-based sample of drivers to determine how ADHD affects driving behavior components.
View Article and Find Full Text PDFAging Cell
January 2025
Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, New York, USA.
Declines in lysosomal acidification and function with aging are observed in organisms ranging from yeast to humans. V-ATPases play a central role in organelle acidification, and V-ATPase activity is regulated by reversible disassembly in many different settings. Using the yeast Saccharomyces cerevisiae as a replicative aging model, we demonstrate that V-ATPases disassemble into their V and V subcomplexes in aging cells, with release of V subunit C (Vma5) from the lysosome-like vacuole into the cytosol.
View Article and Find Full Text PDFPlant Divers
November 2024
Department of Systematic and Evolutionary Botany, University of Zurich, Zurich 8008, Switzerland.
Phylogenetic niche conservatism posits that species tend to retain ancestral ecological traits and distributions, which has been broadly tested for lineages originating in tropical climates but has been rarely tested for lineages that originated and diversified in temperate climates. Liverworts are thought to originate in temperate climates. Mean lineage age reflects evolutionary history of biological communities.
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June 2025
Erasmus MC, Pandemic and Disaster Preparedness Center, Delft, Rotterdam, the Netherlands.
Background: The disease burden of COVID-19 infection, morbidity, and mortality was unevenly distributed across different population subgroups. A one-size-fits-all approach may not reach all groups. Identifying barriers and drivers that influence behaviour towards COVID-19 public health and social measures (PHSM) is an important step when designing tailored interventions.
View Article and Find Full Text PDFInj Epidemiol
January 2025
Injury Prevention Research Center, University of Iowa, 145 N Riverside Dr., Iowa City, IA, 52242, USA.
Background: Motor vehicle crashes are the second leading cause of injury death among adults aged 65 and older in the U.S., second only to falls.
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