Invited for this month's cover are collaborating teams from academia-the French ICPEES and IS2M of Centre national de la recherche scientifique (CNRS) and the Italian ICCOM of Consiglio Nazionale delle Ricerche (CNR)-and industry with the participation of the ORANO group. The cover picture shows a CO -to-CH process promoted by nickel nanoparticles supported on depleted uranium oxide under exceptionally low temperature values or autothermal conditions. The Research Article itself is available at 10.1002/cssc.202201859.
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Mitigation of depleted uranium-induced mitochondrial damage by ethylmalonic encephalopathy 1 protein via modulation of hydrogen sulfide and glutathione pathways.
Arch Toxicol
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State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Depleted uranium (DU) is a byproduct of uranium enrichment, which can cause heavy-metal toxicity and radiation toxicity as well as serious damage to the kidneys. However, the mechanism of renal injury induced by DU is still unclear. This study aimed to explore the role of ethylmalonic encephalopathy 1 (ETHE1) in DU-induced mitochondrial dysfunction and elucidate the underlying mechanisms.
View Article and Find Full Text PDFFine-Tune the Structural Components of Porous Frameworks for Photocatalytic Hydrogen Production.
Chemistry
December 2024
Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Faculty of Chemistry, Northeast Normal University, Changchun, 130024, China.
With the depletion of fossil fuels and increasing pollution problems, green and sustainable energy supply attracts worldwide attention. Hydrogen is a green and high-density energy substance, and photocatalytic hydrogen generation is an effective and sustainable method. Therefore, developing high-performance photocatalysts plays a crucial role in practical application.
View Article and Find Full Text PDFThirty years of surveillance of depleted uranium-exposed Gulf War veterans demonstrate continued effects to bone health.
J Toxicol Environ Health A
November 2024
Department of Veterans Affairs Medical Center Baltimore, MD, USA.
During the spring of 2024, 33 members of a group of Gulf War I veterans wounded in depleted uranium (DU) friendly-fire incidents were seen at the Baltimore VA Medical Center for surveillance related to their combat exposure. The cohort was assessed with a protocol which includes exposure monitoring for total and isotopic uranium (U) concentrations in urine and a comprehensive assessment of health outcomes including measures of bone metabolism and bone mineral density (BMD). An audiometry examination of the cohort was added to assess for acoustic trauma and toxic metal effects in this surveillance episode marking over 30 years since this exposure event.
View Article and Find Full Text PDFMitochondrial-Targeting Mesoporous Polydopamine Nanoparticles for Reducing Kidney Injury Caused by Depleted Uranium.
Adv Healthc Mater
November 2024
State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Article Synopsis
- - Depleted uranium (DU) from the nuclear industry can harm kidneys by causing oxidative damage and inflammation through mitochondrial pathways, leading to health issues.
- - A new nanoparticle, MPDA-PEG-TPP, has been developed to specifically target and protect kidneys from DU injury, showing better bioavailability and targeting compared to existing treatments.
- - Test results indicate that MPDA-PEG-TPP effectively removes harmful reactive oxygen species and alleviates mitochondrial dysfunction, proving to be a promising solution for kidney protection against DU exposure.
Health Implications of Depleted Uranium: An Update.
J Appl Toxicol
November 2024
Xi'an Key Laboratory of Toxicology and Biological Effects, Research Center for Toxicology and Biological Effects, Institute for Hygiene of Ordnance Industry, Xi'an, China.
Depleted uranium (DU), as a heavy metal material extensively utilized in the industrial sector, poses potential health risks to humans through various exposure pathways, including inhalation, ingestion, and dermal contact. To comprehensively understand the toxicological hazards of DU, this study conducted a literature search in the Web of Science Core Collection database using "DU" and "toxicity" as keywords, covering the period from January 2000 to December 2023. A total of 65 papers related to human, animal, or cellular studies on DU were included.
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