This article presents a mixed-mode electronically tunable first-order universal filter configuration employing only one voltage differencing gain amplifier (VDGA), one capacitor, and one grounded resistor. With the appropriate selection of the input signals, the proposed circuit can realize all three first-order standard filter functions, namely low pass (LP), high pass (HP), and all pass (AP), in all four possible modes, including voltage mode (VM), trans-admittance mode (TAM), current mode (CM), and trans-impedance mode (TIM), from the same circuit structure. It also provides an electronic tuning of the pole frequency and the passband gain by varying transconductance values. Non-ideal and parasitic effect analyses of the proposed circuit were also carried out. PSPICE simulations and experimental findings have both confirmed the performance of the design. A number of simulations and experimental observations confirm the viability of the suggested configuration in practical applications.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007470 | PMC |
| http://dx.doi.org/10.3390/s23052759 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mixed-mode separation of antisense oligonucleotides using a single column with complementary anion-exchange and hydrophobic interaction chromatography approaches.
J Chromatogr A
December 2024
Genetics Guided Dementia Discovery (G2D2), Eisai, Inc. 35 Cambridge Park Drive, Suite 200, Cambridge, MA, 02140, USA.
The current study investigates the use of mixed-mode chromatography as a combination of anion-exchange (AEX) and hydrophobic interaction chromatography (HIC) for the analysis and purification of single-stranded antisense oligonucleotides with stereo-controlled phosphorothioate inter- nucleotide linkages. Initially a Scherzo-SS-C18 trimodal stationary phase with reversed-phase/AEX/ cation-exchange (CEX) functionalities is systematically evaluated to reveal the presence of U-shaped retention composed of two retention modes namely AEX and HIC, where the latter was also observed on related trimodal Scherzo SM and SW analogues. For the first time, retention and separation of deprotected oligonucleotides was described on a single mixed-mode column using a combination of AEX and HIC.
View Article and Find Full Text PDFGlutathione-functionalized covalent organic frameworks@silica as a hydrophilic-hydrophobic balanced mixed-mode stationary phase for highly efficient separation of compounds with a wide range of polarity.
Anal Chim Acta
January 2025
School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, 450001, PR China; Key Laboratory of Accurate Separation and Analysis for Complex Matrix of Zhengzhou City, Zhengzhou, 450001, PR China. Electronic address:
Background: Covalent organic frameworks (COFs) are a highly promising stationary phase for high-performance liquid chromatography (HPLC), but the separation of polar compounds is limited by their low hydrophilicity. Therefore, it is crucial to develop novel COFs-based stationary phases with balanced hydrophilicity-hydrophobicity for the efficient separation of different polar compounds.
Results: In this paper, glutathione (GSH)-functionalized COFs@silica microspheres (GSH-COFs@SiO) were synthesized via a two-step, post-synthesis modification strategy.
Two-dimensional liquid chromatography based on different modulations for the determination of Aristolochic Acid Ⅰ in Asari Radix et Rhizoma.
J Chromatogr A
December 2024
Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China. Electronic address:
Asari Radix et Rhizoma (ARR) is a traditional Chinese herbal medicine derived from the genus Asarum in the Aristolochiaceae family, which has been widely used for years. Aristolochic acids in it significantly restrict the clinical application of ARR due to its nephrotoxic and carcinogenic properties, of which aristolochic acid I (AA I) is the most representative. The present paper describes two 2D-LC systems modulated by a sample loop and a trap column respectively for the detection of trace aristolochic acid I in ARR.
View Article and Find Full Text PDFFracture mechanics properties of human cranial bone.
J Mech Behav Biomed Mater
November 2024
School of Mechanical and Materials Engineering, University College Dublin, Dublin, Ireland. Electronic address:
The mechanical properties of the human skull have been examined and established previously in the literature, for example, the transversal isotropy of cranial bone and properties including the Elastic modulus and Poisson's ratio. However, despite the existing data, there are still mechanical properties which remain to be determined for the human skull. The present study aims to characterise the fracture properties of human cranial bone within the Linear Elastic Fracture Mechanics (LEFM) framework.
View Article and Find Full Text PDFApplications of hydrophilic interaction and mixed-mode liquid chromatography in pharmaceutical analysis.
J Chromatogr A
January 2025
Synthetic Molecule Analytical Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:
Hydrophilic Interaction Liquid Chromatography (HILIC) and Mixed-Mode Chromatography (MMC) excel in separating polar, hydrophilic, and charged analytes due to unique hydrophilic or mixed-mode retention mechanisms. They represent a complementary approach to the widely used Reversed Phase Liquid Chromatography (RPLC). Often, where RPLC struggles, HILIC and MMC thrive.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!