Monitoring information can facilitate the condition assessment of railway infrastructure, via delivery of data that is informative on condition. A primary instance of such data is found in Axle Box Accelerations (ABAs), which track the dynamic vehicle/track interaction. Such sensors have been installed on specialized monitoring trains, as well as on in-service On-Board Monitoring (OBM) vehicles across Europe, enabling a continuous assessment of railway track condition. However, ABA measurements come with uncertainties that stem from noise corrupt data and the non-linear rail-wheel contact dynamics, as well as variations in environmental and operational conditions. These uncertainties pose a challenge for the condition assessment of rail welds through existing assessment tools. In this work, we use expert feedback as a complementary information source, which allows the narrowing down of these uncertainties, and, ultimately, refines assessment. Over the past year, with the support of the Swiss Federal Railways (SBB), we have assembled a database of expert evaluations on the condition of rail weld samples that have been diagnosed as critical via ABA monitoring. In this work, we fuse features derived from the ABA data with expert feedback, in order to refine defection of faulty (defect) welds. Three models are employed to this end; Binary Classification and Random Forest (RF) models, as well as a Bayesian Logistic Regression (BLR) scheme. The RF and BLR models proved superior to the Binary Classification model, while the BLR model further delivered a probability of prediction, quantifying the confidence we might attribute to the assigned labels. We explain that the classification task necessarily suffers high uncertainty, which is a result of faulty ground truth labels, and explain the value of continuously tracking the weld condition.
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http://dx.doi.org/10.3390/s23052672 | DOI Listing |
Genet Med
January 2025
Genomics Ethics, and Translational Research Program, RTI International, Research Triangle Park, NC; Department of Translational and Applied Genomics, Kaiser Permanente Center for Health Research, Portland, OR. Electronic address:
Purpose: Limited evidence evaluates parents' perceptions of their child's clinical genomic sequencing (GS) results, particularly among individuals from medically underserved groups. Five Clinical Sequencing Evidence-Generating Research (CSER) consortium studies performed GS in children with suspected genetic conditions with high proportions of individuals from underserved groups to address this evidence gap.
Methods: Parents completed surveys of perceived understanding, personal utility, and test-related distress after GS result disclosure.
J Evid Based Integr Med
January 2025
Department of Biological Sciences, Faculty of Science, Beirut Arab University, Beirut, Lebanon.
Background: Polycystic Ovarian Syndrome (PCOS) is an endocrine disorder associated with increased risk of kidney and liver damage. Current treatments have shown contradictory outcomes, and their long-term use causes unwanted side effects. could serve as a complementary medicine to current PCOS treatments.
View Article and Find Full Text PDFZool Res
January 2025
School of Basic Medicine, Institute of Brain Science and Disease, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Brain Diseases, Qingdao University, Qingdao, Shandong, 266071, China. E-mail:
Iron is the most abundant transition metal in the brain and is essential for brain development and neuronal function; however, its abnormal accumulation is also implicated in various neurological disorders. The olfactory bulb (OB), an early target in neurodegenerative diseases, acts as a gateway for environmental toxins and contains diverse neuronal populations with distinct roles. This study explored the cell-specific vulnerability to iron in the OB using a mouse model of intranasal administration of ferric ammonium citrate (FAC).
View Article and Find Full Text PDFZool Res
January 2025
Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. E-mail:
Animal adaptation to environmental challenges is a complex process involving intricate interactions between the host genotype and gut microbiome composition. The gut microbiome, highly responsive to external environmental factors, plays a crucial role in host adaptability and may facilitate local adaptation within species. Concurrently, the genetic background of host populations influences gut microbiome composition, highlighting the bidirectional relationship between host and microbiome.
View Article and Find Full Text PDFActa Radiol
January 2025
Department of Radiology, Changi General Hospital, Singapore, Republic of Singapore.
Background: Computed tomography (CT) is the gold standard imaging modality for the assessment of 3D bony morphology but incurs the cost of ionizing radiation exposure. High-resolution 3D magnetic resonance imaging (MRI) with CT-like bone contrast (CLBC) may provide an alternative to CT in allowing complete evaluation of both bony and soft tissue structures with a single MRI examination.
Purpose: To review the technical aspects of an optimized stack-of-stars 3D gradient recalled echo pulse sequence method (3D-Bone) in generating 3D MR images with CLBC, and to present a pictorial review of the utility of 3D-Bone in the clinical assessment of common musculoskeletal conditions.
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