AI Article Synopsis

  • Cartilage damage restoration is a challenging process, but Kartogenin (KGN) shows promise by promoting stem cell differentiation and protecting chondrocytes.
  • Researchers successfully created poly(lactic-co-glycolic acid) (PLGA) particles loaded with KGN using electrospray techniques, blending PLGA with hydrophilic polymers (PEG or PVP) to adjust KGN release rates.
  • The resulting particles were small (2.4-4.1 µm), highly efficient in KGN loading (>93%), and exhibited varying release profiles, with some designs allowing for tailored drug release and demonstrating good compatibility with human osteoblasts.

Article Abstract

The restoration of cartilage damage is a slow and not always successful process. Kartogenin (KGN) has significant potential in this space-it is able to induce the chondrogenic differentiation of stem cells and protect articular chondrocytes. In this work, a series of poly(lactic-co-glycolic acid) (PLGA)-based particles loaded with KGN were successfully electrosprayed. In this family of materials, PLGA was blended with a hydrophilic polymer (either polyethyleneglycol (PEG) or polyvinylpyrrolidone (PVP)) to control the release rate. Spherical particles with sizes in the range of 2.4-4.1 µm were fabricated. They were found to comprise amorphous solid dispersions, with high entrapment efficiencies of >93%. The various blends of polymers had a range of release profiles. The PLGA-KGN particles displayed the slowest release rate, and blending with PVP or PEG led to faster release profiles, with most systems giving a high burst release in the first 24 h. The range of release profiles observed offers the potential to provide a precisely tailored profile via preparing physical mixtures of the materials. The formulations are highly cytocompatible with primary human osteoblasts.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007262PMC
http://dx.doi.org/10.3390/polym15051275DOI Listing

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