is a small genus of xylotrophic basidiomycetes and a source of bioactive fungochemicals among which a special place is occupied by polymeric compounds. In this study, polysaccharides that are widespread in Europe, Asia, and North America and a poorly understood fungal species, (Pers.) Karst. (fox polypore), were investigated. Water-soluble polysaccharides of mycelium were extracted, purified, and studied using chemical reactions, elemental and monosaccharide analysis, UV-Vis and FTIR spectroscopy, gel permeation chromatography, and linkage analysis. Five homogenic polymers (IRP-1-IRP-5) with molecular weights of 110-1520 kDa were heteropolysaccharides that consist mainly of galactose, glucose, and mannose. The dominant component, IRP-4, was preliminary concluded to be a branched (1→3,6)-linked galactan. Polysaccharides of inhibited the hemolysis of sensitized sheep erythrocytes by complement from human serum, signifying anticomplementary activity with the greatest effects for the IRP-4 polymer. These findings suggest that mycelium is a new source of fungal polysaccharides with potential immunomodulatory and anti-inflammatory properties.
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| http://dx.doi.org/10.3390/polym15051257 | DOI Listing |
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