The effectiveness of inhalation therapy depends on aerosol size distribution, which determines the penetration and regional deposition of drug in the lungs. As the size of droplets inhaled from medical nebulizers varies depending on the physicochemical properties of the nebulized liquid, it can be adjusted by adding some compounds as viscosity modifiers (VMs) of a liquid drug. Natural polysaccharides have been recently proposed for this purpose and while they are biocompatible and generally recognized as safe (GRAS), their direct influence of the pulmonary structures is unknown. This work studied the direct influence of three natural VMs (sodium hyaluronate, xanthan gum, and agar) on the surface activity of the pulmonary surfactant (PS) measured in vitro using the oscillating drop method. The results allowed for comparing the variations of the dynamic surface tension during breathing-like oscillations of the gas/liquid interface with the PS, and the viscoelastic response of this system, as reflected by the hysteresis of the surface tension. The analysis was done using quantitative parameters, i.e., stability index (SI), normalized hysteresis area (), and loss angle (), depending on the oscillation frequency (). It was also found that, typically, SI is in the range of 0.15-0.3 and increases nonlinearly with , while slightly decreases. The effect of NaCl ions on the interfacial properties of PS was noted, which was usually positive for the size of hysteresis with an value up to 2.5 mN/m. All VMs in general were shown to have only a minor effect on the dynamic interfacial properties of PS, suggesting the potential safety of the tested compounds as functional additives in medical nebulization. The results also demonstrated relationships between the parameters typically used in the analysis of PS dynamics (i.e., and SI) and dilatational rheological properties of the interface, allowing for easier interpretation of such data.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004148PMC
http://dx.doi.org/10.3390/ma16051975DOI Listing

Publication Analysis

Top Keywords

viscosity modifiers
8
dynamic surface
8
pulmonary surfactant
8
direct influence
8
surface tension
8
interfacial properties
8
properties
5
impact natural-based
4
natural-based viscosity
4
modifiers inhalation
4

Similar Publications

Fluidity influences the use of backfill materials in the mining industry. A new backfill material-modified magnesium slag-based backfill materials (MFPB)-is made from solid waste from coal and metallurgy. We focus on the compatibility of polycarboxylate water reducing agent (SP) with MFPB and its effect on MFPB performance.

View Article and Find Full Text PDF

In our previous work, wheat gluten (WG) has been modified by pH-shifting treatment combined with heat to improve solubility and emulsibility. In this study, the high-soluble modified wheat gluten (M-WG) as an emulsifier in ice cream was investigated. Compared to monoglycerides (MG) and soy protein isolates (SPI), the ice cream emulsion prepared with M-WG exhibited smaller droplet sizes and a more consistent dispersion.

View Article and Find Full Text PDF

Fully-convolutional neural networks (FCN) were proven to be effective for predicting the instantaneous state of a fully-developed turbulent flow at different wall-normal locations using quantities measured at the wall. In Guastoni et al. (J Fluid Mech 928:A27, 2021.

View Article and Find Full Text PDF

Synergistic modification of ovalbumin by pH-driven and metal-phenolic networks: Development of dysphagia friendly high internal phase Pickering emulsions.

Int J Biol Macromol

December 2024

School of Medicine and Health, Harbin Institute of Technology, Harbin 150001, China; Institute of Plant Virology, Ningbo University, Ningbo 315211, China; Chongqing Research Institute, Harbin Institute of Technology, Chongqing 401135, China. Electronic address:

Dysphagia is a common functional disorder that limits the variety of available foods. This study explored the coordination assembly of tannic acid (TA) with Fe to form a metal-phenolic network (MPN) and developed ovalbumin (OVA)/MPN via a pH-driven method as a novel emulsifier to stabilize high internal phase Pickering emulsions (HIPPEs). Results indicated that, following pH-driven treatment, the OVA/MPN composite particles exhibited smaller sizes, enhanced electrostatic repulsion, and improved stability.

View Article and Find Full Text PDF

Formulation and characterization of low-fat breakfast cream using conjugated whey protein and modified starch.

Int J Biol Macromol

December 2024

Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran; Halal Research Center of IRI, Iran Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran.

This study investigates the impact of conjugating whey protein (WP) with modified starch (MS), utilizing the Maillard reaction, on the characteristics of low-fat breakfast cream. The combination of WP and MS is significant due to its potential to improve the nutritional profile and textural attributes of low-fat dairy products, in response to consumer demand for healthier options. Various cream formulations were prepared with different ratios and concentrations of WP-MS conjugates, and their texture, water holding capacity, and sensory attributes were systematically analyzed.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!