AI Article Synopsis
- - The study aims to analyze the prevalence of multiple sclerosis (MS) in Italian patients with endometriosis (EMS) by examining a population from a referral center and exploring the clinical and immune profiles of enrolled patients.
- - Out of 1652 women with EMS, only 9 were also diagnosed with MS, showing a prevalence rate of 0.005%, and the conditions appeared in mild forms for the majority.
- - The findings indicate a potential increased risk of MS in women with EMS, but researchers emphasize the need for larger and more comprehensive studies to confirm these associations.
Article Abstract
Objective: To report for the first time an Italian epidemiological analysis of the prevalence of multiple sclerosis (MS) in patients with endometriosis (EMS), through the study of the endometriosis population of our referral center; to analyze the clinical profile and perform a laboratory analysis to examine the immune profile and the possible correlation to other autoimmune diseases of the enrolled patients.
Methods: We evaluated 1652 women registered with EMS in the University of Naples Federico II and retrospectively searched patients with a co-diagnosis of MS. Clinical features of both conditions were recorded. Serum autoantibody and immune profiles were analyzed.
Results: 9 out of 1652 patients presented a co-diagnosis of EMS and MS (9/1652 = 0.005%). Clinically, EMS and MS presented in mild forms. Hashimoto's thyroiditis was found in two patients (2/9). Even if not statistically significant, a trend of variation in CD4- CD8 T lymphocytes and of B cells were found.
Conclusion: Our findings suggest an increased risk of MS in women with EMS. However, large-scale prospective studies are needed.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004013 | PMC |
| http://dx.doi.org/10.3390/jcm12052043 | DOI Listing |
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