Design, Synthesis and Bioactivity of Novel Pyrimidine Sulfonate Esters Containing Thioether Moiety.

Pesticides play an important role in crop disease and pest control. However, their irrational use leads to the emergence of drug resistance. Therefore, it is necessary to search for new pesticide-lead compounds with new structures. We designed and synthesized 33 novel pyrimidine derivatives containing sulfonate groups and evaluated their antibacterial and insecticidal activities. Results: Most of the synthesized compounds showed good antibacterial activity against pv. (), pv. (), pv. () and (Rs), and certain insecticidal activity. , and showed strong antibacterial activity against , with EC values of 4.24, 6.77 and 9.35 μg/mL, respectively. Compounds , , and showed remarkable activity against (EC was 79.02, 82.28, 70.80 and 44.11 μg/mL, respectively). In addition, could significantly improve the defense enzyme (superoxide dismutase, peroxidase, phenylalanine ammonia-lyase and catalase) activity of plants against pathogens and thus improve the disease resistance of plants. Moreover, a few compounds also showed good insecticidal activity against and . The results of this study provide insight into the development of new broad-spectrum pesticides.