AI Article Synopsis
- MMP12, also known as macrophage metalloelastase, is crucial for breaking down components in the extracellular matrix and has been linked to periodontal diseases.
- Recent findings indicate MMP12 is involved in various oral health issues, such as periodontitis, temporomandibular joint dysfunction, and oral cancers.
- Further research is needed to clarify MMP12's specific role in these conditions, which could lead to new treatment strategies for related inflammatory oral diseases.
Article Abstract
Matrix metalloproteinase-12 (MMP12), or macrophage metalloelastase, plays important roles in extracellular matrix (ECM) component degradation. Recent reports show MMP12 has been implicated in the pathogenesis of periodontal diseases. To date, this review represents the latest comprehensive overview of MMP12 in various oral diseases, such as periodontitis, temporomandibular joint dysfunction (TMD), orthodontic tooth movement (OTM), and oral squamous cell carcinoma (OSCC). Furthermore, the current knowledge regarding the distribution of MMP12 in different tissues is also illustrated in this review. Studies have implicated the association of MMP12 expression with the pathogenesis of several representative oral diseases, including periodontitis, TMD, OSCC, OTM, and bone remodelling. Although there may be a potential role of MMP12 in oral diseases, the exact pathophysiological role of MMP12 remains to be elucidated. Understanding the cellular and molecular biology of MMP12 is essential, as MMP12 could be a potential target for developing therapeutic strategies targeting inflammatory and immunologically related oral diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002488 | PMC |
| http://dx.doi.org/10.3390/ijms24054648 | DOI Listing |
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