AI Article Synopsis
- Diabetes mellitus is a major cause of chronic wounds and non-traumatic amputations, with its prevalence on the rise globally.
- The dysfunction of keratinocytes, the skin cells vital for wound healing, is exacerbated by high glucose levels, leading to issues like prolonged inflammation and poor healing.
- Understanding the molecular mechanisms behind keratinocyte dysfunction in high glucose conditions can help develop effective treatments for diabetic wound healing.
Article Abstract
Diabetes mellitus (DM) is an important cause of chronic wounds and non-traumatic amputation. The prevalence and number of cases of diabetic mellitus are increasing worldwide. Keratinocytes, the outermost layer of the epidermis, play an important role in wound healing. A high glucose environment may disrupt the physiologic functions of keratinocytes, resulting in prolonged inflammation, impaired proliferation, and the migration of keratinocytes and impaired angiogenesis. This review provides an overview of keratinocyte dysfunctions in a high glucose environment. Effective and safe therapeutic approaches for promoting diabetic wound healing can be developed if molecular mechanisms responsible for keratinocyte dysfunction in high glucose environments are elucidated.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002069 | PMC |
| http://dx.doi.org/10.3390/ijms24054290 | DOI Listing |
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