Much research has been conducted in an attempt to decrease skeletal injuries in athletic horses. The objective of this literature review is to compile the findings of over three decades of research in this area, make practical recommendations, and describe how research can develop over the years. An initial study investigating the role of bioavailable silicon in the diets of horses in race training produced the unexpected finding of decreased bone mineral content of the third metacarpus subsequent to the onset of training. Further studies revealed this decrease to be associated with stall housing eliminating high-speed exercise, leading to disuse osteopenia. Only relatively short sprints (between 50 and 82 m) were necessary to maintain bone strength and as few as one sprint per week provided the needed stimuli. Endurance exercise without speed fails to elicit the same benefits to bone. Proper nutrition is also required for optimal bone health, but without the right exercise, strong bone cannot be maintained. Several pharmaceuticals may have unintended consequences capable of impairing bone health. Many of the factors influencing bone health in horses also exist in humans including a sedentary lifestyle, improper nutrition, and pharmaceutical side-effects.
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http://dx.doi.org/10.3390/ani13050789 | DOI Listing |
Purpose: This study aimed to elucidate the correlation between the degree of fat infiltration (FI) in thoracic paraspinal muscles and thoracic vertebral degeneration (TVD).
Methods: This cross-sectional study comprised 474 patients who underwent standard thoracic computed tomography (CT) scans. The FI was quantified as the percentage of adipose tissues within the cross-sectional area of thoracic paraspinal muscles.
Bone Res
January 2025
National Institute of Biological Sciences, Beijing (NIBS), 102206, Beijing, China.
Tissue clearing combined with high-resolution confocal imaging is a cutting-edge approach for dissecting the three-dimensional (3D) architecture of tissues and deciphering cellular spatial interactions under physiological and pathological conditions. Deciphering the spatial interaction of leptin receptor-expressing (LepR) stromal cells with other compartments in the bone marrow is crucial for a deeper understanding of the stem cell niche and the skeletal tissue. In this study, we introduce an optimized protocol for the 3D analysis of skeletal tissues, enabling the visualization of hematopoietic and stromal cells, especially LepR stromal cells, within optically cleared bone hemisections.
View Article and Find Full Text PDFJ Transl Med
January 2025
Department of Joint Surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Rotator cuff injury (RCI), characterized by shoulder pain and restricted mobility, represents a subset of tendon-bone insertion injuries (TBI). In the majority of cases, surgical reconstruction of the affected tendons or ligaments is required to address the damage. However, numerous clinical failures have underscored the suboptimal outcomes associated with such procedures.
View Article and Find Full Text PDFCell Commun Signal
January 2025
Department of Cell and Molecular Biology, College of Medicine, Chang Gung University, 259 Wen-Hwa 1 road, Guishan District, Taoyuan, Taiwan.
Background: The Golgi apparatus is widely considered a secretory center and a hub for different signaling pathways. Abnormalities in Golgi dynamics can perturb the tumor microenvironment and influence cell migration. Therefore, unraveling the regulatory network of the Golgi and searching for pharmacological targets would facilitate the development of novel anticancer therapies.
View Article and Find Full Text PDFJ Cyst Fibros
January 2025
The Lundquist Institute, Harbor-UCLA Medical Center, Torrance 90502 CA, USA. Electronic address:
Background: Cystic Fibrosis-related Bone Disease is an emerging challenge faced by 50 % of adult people with cystic fibrosis (CF). The multifactorial causes of this comorbidity remain elusive. However, congenital bone defects have been observed in animal models with CFTR mutations, suggesting its importance.
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