Background: This study aims to investigate the value of myocardial work (MW) parameters during the isovolumic relaxation (IVR) period in patients with left ventricular diastolic dysfunction (LVDD).
Methods: This study prospectively recruited 448 patients with risks for LVDD and 95 healthy subjects. An additional 42 patients with invasive measurements of left ventricular (LV) diastolic function were prospectively included. The MW parameters during IVR were noninvasively measured using EchoPAC.
Results: The total myocardial work during IVR (MW), myocardial constructive work during IVR (MCW), myocardial wasted work during IVR (MWW), and myocardial work efficiency during IVR (MWE) of these patients were 122.5 ± 60.1 mmHg%, 85.7 ± 47.8 mmHg%, 36.7 ± 30.6 mmHg%, and 69.4 ± 17.8%, respectively. The MW during IVR was significantly different between patients and healthy subjects. For patients, MWE and MCW were significantly correlated with the LV E/e' ratio and left atrial volume index, MWE exhibited a significant correlation with the maximal rate of decrease in LV pressure (dp/dt per min) and tau, and the MWE corrected by IVRT also exhibited a significant correlation with tau.
Conclusions: MW during IVR significantly changes in patients with risks for LVDD, and is correlated to LV conventional diastolic indices, including dp/dt min and tau. Noninvasive MW during IVR may be a promising tool to evaluate the LV diastolic function.
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http://dx.doi.org/10.1186/s12872-023-03156-4 | DOI Listing |
Magn Reson Imaging
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Department of Radiology, Iwate Medical University, Yahaba, Japan.
Objective: The total examination time can be reduced if high-quality two-dimensional (2D) cine images can be collected post-contrast to minimize non-scanning time prior to late gadolinium-enhanced imaging. This study aimed to assess the equivalency of the pre-and post-contrast performance of 2D deep learning-based highly accelerated cardiac cine (DL cine) imaging by evaluating the image quality and the quantification of biventricular volumes and function in the clinical setting.
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Lancet Rheumatol
December 2024
Academic Rheumatology, School of Medicine, Nottingham City Hospital, University of Nottingham, Nottingham, UK; National Institute for Health and Care Research Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.
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View Article and Find Full Text PDFEur J Radiol
December 2024
Department of Biostatistics, University of Iowa, Iowa City, IA, USA.
Rationale And Objectives: To investigate the effect of ComBat harmonization on the stability of myocardial radiomic features derived from multi-energy CT reconstructions.
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JACC Heart Fail
December 2024
Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address:
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Am J Cardiovasc Drugs
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Department of Pharmacy, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Nicotinamide adenine dinucleotide (NAD) is a promising anti-aging molecule that plays a role in cellular energy metabolism and maintains redox homeostasis. Additionally, NAD is involved in regulating deacetylases, DNA repair enzymes, inflammation, and epigenetics, making it indispensable in maintaining the basic functions of cells. Research on NAD has become a hotspot, particularly regarding its potential in cardiovascular disease (CVD).
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