AI Article Synopsis
- Pharmaceutical industries and regulatory agencies are shifting towards continuous manufacturing to enhance product quality and processing control.
- The study focused on the continuous manufacturing of an oil-in-water emulgel using lidocaine, characterized by various parameters such as pH and globule size.
- Findings showed that a screw speed of 300 rpm at 25°C yielded smaller globules and quicker drug release compared to other speeds and temperatures.
Article Abstract
Pharmaceutical industries and drug regulatory agencies are inclining towards continuous manufacturing due to better control over the processing conditions and in view to improve product quality. In the present work, continuous manufacturing of O/W emulgel by melt extrusion process was explored using lidocaine as an active pharmaceutical ingredient. Emulgel was characterized for pH, water activity, globule size distribution, and in vitro release rate. Additionally, effect of temperature (25°C and 60°C) and screw speed (100, 300, and 600 rpm) on the globule size and in vitro release rate was studied. Results indicated that at a given temperature, emulgel prepared under screw speed of 300 rpm resulted in products with smaller globules and faster drug release.
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| http://dx.doi.org/10.1208/s12249-023-02530-x | DOI Listing |
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