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| http://dx.doi.org/10.1002/ana.26637 | DOI Listing |
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Lutein, a versatile carotenoid: Insight on neuroprotective potential and recent advances.
Phytomedicine
December 2024
School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore 632014, India. Electronic address:
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- * The pigment lutein has shown promise as a potential treatment for NDDs by enhancing brain development, cognitive function, and neuroplasticity while displaying neuroprotective effects against conditions like Alzheimer's and Parkinson's.
- * Lutein's protective actions include reducing oxidative stress, preventing neuroinflammation, and supporting neurogenesis, suggesting it could be a valuable natural therapeutic agent for combating NDDs.
Aberrance of GAP43/p-GAP43 Closely Associates with the Pathology of Neuron Loss in Prion-Infected Rodent Models.
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National Key-Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, NHC Key Laboratory of Medical Virology and Viral Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Zhejiang University), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Prion diseases are fatal neurodegenerative disorders characterized by neuron damage and loss. Growth-associated protein 43 (GAP43) functions in neuronal plasticity and synaptic function, but its role in prion diseases is not fully elucidated. In this study, we investigated the changes of GAP43 in the central nerve system (CNS) of several prion-infected rodent models and explored the potential relationship of GAP43 with PrP deposit and neuron loss using various methods.
View Article and Find Full Text PDFThe potential toxic effects of estrogen exposure on neural and vascular development in zebrafish.
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Engineering Research Center of Key Technique for Biotherapy of Guangdong Province, Shantou University Medical College, Shantou 515041, China. Electronic address:
Estrogens and estrogenic chemicals are endocrine-disrupting chemicals (EDCs). The potential toxicity of EDCs to humans and aquatic organisms has become increasingly concerning. However, at present, the potential toxic mechanisms of EDCs on neural and vascular development are still being fully investigated.
View Article and Find Full Text PDFGene expression patterns and DNA methylation of neuron and pancreatic β-cell developments in zebrafish embryos treated with bisphenol F and AF.
Heliyon
July 2024
Institute of Environmental Health and Ecological Security, School of Environment and Safety Engineering, Jiangsu University, Zhenjiang, 212013, China.
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- - Zebrafish exposed to BPF and BPAF showed significant behavioral changes, increased glucose levels, and decreased insulin-related gene expression, indicating potential developmental disruptions.
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Unveiling impaired vascular function and cellular heterogeneity in diabetic donor-derived vascular organoids.
Stem Cells
September 2024
The Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, BT9 7BL, United Kingdom.
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- Vascular organoids (VOs) from induced pluripotent stem cells (iPSCs) show promise as models for studying human vascular diseases and drug testing, but their effectiveness in mimicking actual human conditions needs further exploration.
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