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Differentiating Multisystem Inflammatory Syndrome in Children (MIS-C) and Its Mimics - A Single-Center Experience From a Tropical Setting. | LitMetric

AI Article Synopsis

  • The study aimed to identify clinical and laboratory indicators to distinguish multisystem inflammatory syndrome in children (MIS-C) from other febrile diseases in a tropical setting.
  • Researchers reviewed hospital records of children admitted between April 2020 and June 2021, analyzing 114 cases considered for MIS-C based on symptoms.
  • The findings indicated that older age, specific symptoms like mucocutaneous issues, high C-reactive protein, neutrophilic leukocytosis, abdominal pain, and lack of hepatosplenomegaly are key indicators favoring a diagnosis of MIS-C.

Article Abstract

Objective: Identifying clinical and laboratory indicators that differentiate multisystem inflam-matory syndrome in children (MIS-C) apart from other febrile diseases in a tropical hospital setting.

Methods: Review of hospital records done in a tertiary care exclusive children's hospital for children admitted from April, 2020 till June, 2021. Laboratory values, severe acute respiratory syndrome coronavirus (SARS-CoV-2) serological status, and clinical signs and symptoms of patients with MIS-C, and those with similar presentations were analyzed.

Results: 114 children fulfilled the inclusion criteria (age group of 1 mo-18 y) for whom a diagnosis of MIS-C was considered in the emergency room based on the clinical features. Among them, 64 children had the final diagnosis of MIS-C, and the remaining 50 children had confirmatory evidence of infections mimicking MIS-C such as enteric fever, scrub typhus, dengue and appendicitis.

Conclusion: Older age group, presence of muco-cutaneous symptoms, very high C-reactive protein, neutrophilic leukocytosis, abdominal pain and absence of hepatosplenomegaly favor a diagnosis of MIS-C.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185926PMC
http://dx.doi.org/10.1007/s13312-023-2884-3DOI Listing

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