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Rare DDX3X Gene Mutation in a Male Newborn With Super-refractory Status Epilepticus Responding to Lacosamide Drug Therapy.
Cureus
December 2024
Pediatric Neurology, Bahrain Defence Force Hospital, Riffa, BHR.
Super-refractory status epilepticus (SRSE) is defined as status epilepticus that persists or recurs after treatment with anesthetic agents for more than 24 hours, including cases with recurrent seizures on reduction or withdrawal of anesthetic drugs. Super-refractory status epilepticus presents a significant challenge for neurologists, particularly when standard treatments fail to achieve seizure control. Lacosamide, which has a unique mechanism involving modulating voltage-gated sodium channels by enhancing their slow inactivation, has emerged as a potential option for managing SRSE.
View Article and Find Full Text PDFCombining a WT1 Vaccine (Galinpepimut-S) With Checkpoint Inhibition (Nivolumab) in Patients With WT1-Expressing Diffuse Pleural Mesothelioma: A Phase 1 Study.
JTO Clin Res Rep
January 2025
Thoracic Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York City, NY, USA.
Introduction: WT1 often presents on the surface of diffuse pleural mesotheliomas (DPMs) and is an ideal therapeutic target. Galinpepimut-S (GPS), a tetravalent, non-human leukocyte antigen-restricted, heteroclitic WT1-specific peptide vaccine was safe and effective in early phase clinical trials and upregulates T-cell suppressive programmed death-ligand 1 in the tumor microenvironment of other malignancies. A randomized phase 2 study of adjuvant GPS in patients with DPM trended toward improved median overall survival.
View Article and Find Full Text PDFTreatment Considerations for Pyoderma Gangrenosum After Reduction Mammoplasty in an Unsuspecting Patient Demographic.
Plast Reconstr Surg Glob Open
January 2025
NH Skin Cancer Surgery, LLC, Derry, NH.
Pyoderma gangrenosum (PG) is a rare, often idiopathic, noninfectious inflammatory neutrophilic dermatitis that causes painful ulcerative cutaneous papillomatous lesions. PG often mimics surgical infection, wound dehiscence, and postoperative cellulitis, leading to high rates of misdiagnosis and mistreatment. Here, a healthy 17-year-old adolescent girl with congenital breast asymmetry, macromastia, and a history of only mild intermittent autoimmune conditions developed an open wound along her inferior left breast incision 2 weeks after reduction mammoplasty.
View Article and Find Full Text PDFIntelligent two-phase dual authentication framework for Internet of Medical Things.
Sci Rep
January 2025
Department of Computer Science, College of Computer and Information Sciences, King Saud University, Riyadh, 11543, Saudi Arabia.
The Internet of Medical Things (IoMT) has revolutionized healthcare by bringing real-time monitoring and data-driven treatments. Nevertheless, the security of communication between IoMT devices and servers remains a huge problem because of the inherent sensitivity of the health data and susceptibility to cyber threats. Current security solutions, including simple password-based authentication and standard Public Key Infrastructure (PKI) approaches, typically do not achieve an appropriate balance between security and low computational overhead, resulting in the possibility of performance bottlenecks and increased vulnerability to attacks.
View Article and Find Full Text PDFA Modular AI-Driven Intrusion Detection System for Network Traffic Monitoring in Industry 4.0, Using Nvidia Morpheus and Generative Adversarial Networks.
Sensors (Basel)
December 2024
Department of Automation and Industrial Informatics, Faculty of Automatic Control and Computer Sciences, National University of Science and Technology Polithenica Bucharest, 313 Spl. Independenței, RO060042 Bucharest, Romania.
Every day, a considerable number of new cybersecurity attacks are reported, and the traditional methods of defense struggle to keep up with them. In the current context of the digital era, where industrial environments handle large data volumes, new cybersecurity solutions are required, and intrusion detection systems (IDSs) based on artificial intelligence (AI) algorithms are coming up with an answer to this critical issue. This paper presents an approach for implementing a generic model of a network-based intrusion detection system for Industry 4.
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