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Genetic propensity for cerebral amyloidosis and risk of mild cognitive impairment and Alzheimer's disease within a cognitive reserve framework. | LitMetric
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Genetic propensity for cerebral amyloidosis and risk of mild cognitive impairment and Alzheimer's disease within a cognitive reserve framework.

Niki Mourtzi Sokratis Charisis Angeliki Tsapanou Eva Ntanasi Alexandros Hatzimanolis Alfredo Ramirez Stefanie Heilmann-Heimbach Benjamin Grenier-Boley Jean-Charles Lambert Mary Yannakoulia Mary Kosmidis Efthimios Dardiotis Georgiios Hadjigeorgiou Paraskevi Sakka Marios Georgakis Stern Yaakov Nikolaos Scarmeas

Alzheimers Dement

1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Published: September 2023

AI Article Synopsis

  • Researchers developed a polygenic risk score (PRSAβ42) to assess the likelihood of Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI), while also exploring how cognitive reserve (CR), measured by years of education, affects this risk.
  • In a study involving 618 cognitively normal individuals over an average of nearly 3 years, they used COX models to analyze the relationship between PRSAβ42, CR, and the incidence of AD/aMCI.
  • Findings indicated that higher PRSAβ42 correlated with increased risk of AD/aMCI, while greater CR was associated with reduced risk, highlighting a significant interaction where high CR offered substantial protection against AD/aMCI particularly among

Article Abstract

Introduction: We constructed a polygenic risk score (PRS) for β-amyloid (PRSAβ42) to proxy AD pathology and investigated its association with incident Alzheimer's disease (AD)/amnestic mild cognitive impairment (aMCI) and the influence of cognitive reserve (CR), proxied by educational years, on the relationship between PRSAβ42 and AD/aMCI risk.

Methods: A total of 618 cognitive-normal participants were followed-up for 2.92 years. The association of PRSAβ42 and CR with AD/aMCI incidence was examined with COX models. Then we examined the additive interaction between PRSAβ42 and CR and the CR effect across participants with different PRSAβ42 levels.

Results: Higher PRSAβ42 and CR were associated with a 33.9% higher risk and 8.3% less risk for AD/aMCI, respectively. An additive interaction between PRSAβ42 and CR was observed. High CR was associated with 62.6% less risk of AD/aMCI incidence only in the high-PRSAβ42 group.

Discussion: A super-additive effect of PRSAβ42 and CR on AD/aMCI risk was observed. CR influence was evident in participants with high PRSAβ42.

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 Source
http://dx.doi.org/10.1002/alz.12980DOI Listing

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