AI Article Synopsis
- Thyroid hormones help keep our bodies in balance and are really important for our health.
- Deiodinases are special proteins that change the main thyroid hormone (T4) into a more active form (T3) and also help turn them into inactive forms.
- The review talks about how liver deiodinases affect the amount of thyroid hormones in our blood and liver, and how this can connect to liver health and diseases.
Article Abstract
Thyroid hormones play an essential role in regulating whole-body homeostasis. Deiodinases are known to convert thyroid hormone from the prohormone thyroxine (T4) to the bioactive hormone tri-iodothyronine (T3) and convert both T4 and T3 toward their inactive metabolites 3,3',5'-tri-iodothyronine (rT3) and 3,3'-di-iodothyronine (3,3'-T2). Deiodinases are thus important for the regulation of intracellular thyroid hormone concentrations. This is known to be crucial both during development and adult life in regulating thyroid hormone-related gene transcription. This review discusses the importance of liver deiodinases in determining serum and liver thyroid hormone concentrations, liver metabolism and liver disease.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160546 | PMC |
| http://dx.doi.org/10.1530/ETJ-22-0211 | DOI Listing |
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