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Substrate identification of putative NCS1 and NCS2 nucleobase transporters in .
mBio
December 2024
Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Unlabelled: is an opportunistic pathogen that can salvage nucleobases from the environment to conserve nutrients that would otherwise be spent on nucleotide biosynthesis. However, little is known regarding the substrate specificity of the 13 putative nucleobase transporters in . Here, using a combination of genetic and chemical approaches, we report substrate identifications for 10 putative nucleobase transporters in .
View Article and Find Full Text PDFDevelopment and implementation of a clinical decision support system-based quality initiative to reduce central line-associated bloodstream infections.
J Clin Transl Sci
September 2024
Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Background: Central venous lines (CVLs) are frequently utilized in critically ill patients and confer a risk of central line-associated bloodstream infections (CLABSIs). CLABSIs are associated with increased mortality, extended hospitalization, and increased costs. Unnecessary CVL utilization contributes to CLABSIs.
View Article and Find Full Text PDFSuperomniphobic and Photoactive Surface Presents Antimicrobial Properties by Repelling and Killing Pathogens.
ACS Appl Mater Interfaces
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Department of Engineering Physics, McMaster University, Hamilton L8S 4L7, Ontario, Canada.
Healthcare-acquired infections place a significant burden on the cost and quality of patient care in hospitals. Reducing contamination on surfaces within healthcare environments is critical for halting the spread of these infections. Herein, we report a bifunctional─repel and kill─surface developed using photoactive TiO nanoparticles integrated into a hierarchical scaffold (OmniKill).
View Article and Find Full Text PDFAuthor response: Quantifying healthcare-acquired coronavirus disease 2019 (COVID-19) in hospitalized patients: A closer look.
Infect Control Hosp Epidemiol
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Department of Medicine, Rush University Medical Center, Chicago, Illinois.
Quantifying healthcare-acquired coronavirus disease 2019 (COVID-19) in hospitalized patients: A closer look.
Infect Control Hosp Epidemiol
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Department of Medicine, Mercy Hospital-St. Louis, St. Louis, Missouri63141.
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