AI Article Synopsis
- Eleven bovine, 19 porcine, and 3 ovine picornaviruses were tested against viral inhibitors HBB and GHC1 to assess their growth and pathogenicity.
- Nine bovine viruses were inhibited by both compounds and caused severe skeletal myonecrosis in mice, indicating potential harm similar to human coxsackie viruses.
- One bovine virus (VH7) displayed unique inhibition characteristics and caused muscle damage, while porcine and ovine viruses showed no significant inhibition or harmful effects in the mouse model.
Article Abstract
Eleven bovine, 19 porcine, and 3 ovine picornaviruses were tested for their ability to grow in the presence of the viral inhibitors 2-(alpha-hydroxy-benzyl)- benzimidazole (HBB) and guanidine-HC1 (GHC1). The nature of the lesions produced by inoculation of newborn mice with these viruses was also investigated. Nine bovine viruses were inhibited by both compounds, and produced skeletal myonecrosis in mice, suggesting similarities to the human coxsackie group B viruses and indicating potential pathogenicity for bovine species. One bovine virus (VH7) was inhibited by GHC1 but not by HBB and caused widespread skeletal muscle damage in mice typical of coxsackie group A viruses. Another bovine virus (F266a) was inhibited only by HBB. None of the porcine or ovine viruses showed significant inhibition by either compound nor produced lesions in mice.
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| http://dx.doi.org/10.1007/BF01310733 | DOI Listing |
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