Gliosarcoma (GS) is an extraordinarily rare variant of glioblastoma, which is differentiated by its distinct biphasic histopathological morphology consisting of both glial and mesenchymal elements. Although GS has a predilection for the cortical hemispheres, rare occurrences of intraventricular gliosarcoma (IVGS) have been documented in the literature. In this report, we present a 68-year-old female patient with a primary IVGS arising from the frontal horn of the left ventricle with corresponding left ventricular entrapment. The clinical course as well as associated tumor features as observed on computed tomography (CT), magnetic resonance imaging (MRI), and immunohistochemical studies are presented along with a relevant review of the current literature.
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http://dx.doi.org/10.7759/cureus.34622 | DOI Listing |
Mod Pathol
February 2024
Pathology Unit, Department of Laboratories, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; Department of Medico-surgical Sciences and Biotechnologies, Sapienza University, Rome, Italy.
Radiol Case Rep
January 2023
Department of Radiology, Pham Ngoc Thach University of Medicine, 2 Duong Quang Trung, Ward 12, District 10, Ho Chi Minh City 700000, Vietnam.
A peculiar subtype of glioblastoma multiforme is gliosarcoma. According to histological analysis, it possesses a biphasic shape that clearly distinguishes between glial and sarcomatous tissue. A gliosarcoma is often seen in the supratentorial region.
View Article and Find Full Text PDFRadiol Case Rep
March 2022
Department of Radiology, E Hospital, Hanoi, Vietnam.
Gliosarcoma (GS) is an uncommon central nervous system tumor with several characteristics of a malignant neoplasm and poor prognosis. The majority of GS reports describe a predilection for the cerebral hemispheres, and cases of intraventricular GS are extremely rare, with only a few reported. In addition, intraventricular GS has not been associated with any unique radiographic or clinical features, which can result in misdiagnosis as other intraventricular tumor types.
View Article and Find Full Text PDFSurg Neurol Int
November 2020
Department of Neurosurgery, General Hospital of Fortaleza, Fortaleza, Ceara, Brazil.
Background: Gliosarcoma (GS) is classified as an IDH-wild-type variant of glioblastoma (GBM). While GS is already an unusual presentation of GBM, IDH1-mutant cases are especially rare. We present an IDH1-mutant primary intraventricular GS case report and a systematic review of the molecular profile in GS correlating to the prognostic and pathogenesis of IDH1/2 mutations.
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