Application of Immunohistochemistry in Clinical Practices as a Standardized Assay for Breast Cancer.

Acta Histochem Cytochem

Division of Oncologic Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Ohyaguchikami-cho 30-1, Itabashi-ku, Tokyo 173-8610, Japan.

Published: February 2023

AI Article Synopsis

  • Immunohistochemistry (IHC) is a crucial technique used in breast cancer diagnosis and treatment, allowing for the identification of specific proteins in tissue samples.
  • Despite its significance, there are still many challenges in standardizing IHC results across different laboratories, impacting its reliability and consistency.
  • The review discusses the evolution of IHC, highlights existing problems, and suggests potential solutions and future approaches to improve its clinical use.

Article Abstract

Immunohistochemistry (IHC) has become an indispensable tool in the clinical practices for breast cancer; however, to achieve its standardization, numerous issues need to be overcome. In this review, we describe the development of IHC as an important clinical tool, and the challenges in standardizing IHC results for patients. We also present ideas for resolving the remaining issues and unmet needs, along with future directions.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986307PMC
http://dx.doi.org/10.1267/ahc.22-00050DOI Listing

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