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, a Rosetta stone to understanding bacterial pathogenesis.
J Bacteriol
December 2024
Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
is an environmentally acquired pathogen that causes respiratory disease in humans. While the discovery of is relatively recent compared to other bacterial pathogens, over the past 50 years, has emerged as a powerhouse for studying host-pathogen interactions. In its natural habitat of fresh water, interacts with a diverse array of protozoan hosts and readily evolve to expand their host range.
View Article and Find Full Text PDFRosetta stone for the population dynamics of spiking neuron networks.
Phys Rev E
September 2024
National Center for Radioprotection and Computational Physics, Istituto Superiore di Sanità, 00169 Roma, Italy.
Populations of spiking neuron models have densities of their microscopic variables (e.g., single-cell membrane potentials) whose evolution fully capture the collective dynamics of biological networks, even outside equilibrium.
View Article and Find Full Text PDFWe present a comprehensive study on the best practices for integrating first principles simulations in experimental quadrupolar solid-state nuclear magnetic resonance (SS-NMR), exploiting the synergies between theory and experiment for achieving the optimal interpretation of both. Most high performance materials (HPMs), such as battery electrodes, exhibit complex SS-NMR spectra due to dynamic effects or amorphous phases. NMR crystallography for such challenging materials requires reliable, accurate, efficient computational methods for calculating NMR observables from first principles for the transfer between theoretical material structure models and the interpretation of their experimental SS-NMR spectra.
View Article and Find Full Text PDFGeneration and analysis of mouse embryonic stem cells with knockout of the Mcph1 (microcephalin) gene.
Vavilovskii Zhurnal Genet Selektsii
September 2024
Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, Russia.
Article Synopsis
- Chromatin is organized in a specific three-dimensional structure within the nucleus, crucial for genome functions, with proteins like cohesin and condensins helping in this organization.
- The study reveals that knockout of the Mcph1 gene in mouse embryonic stem cells leads to chromosomal issues and deregulated gene expression, particularly affecting metabolism and olfactory receptors, but not cell cycle control.
- The findings suggest that Mcph1 plays a critical role in maintaining genome integrity and offer insights into the function of condensin II, potentially providing a model for future research on chromatin structure and gene expression.
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