Objective: To evaluate the impact of bleomycin/etoposide/cisplatin (BEP) and paclitaxel/carboplatin (PC) chemotherapy regimens on the fertility and prognostic outcomes in malignant ovarian germ cell tumor (MOGCT) patients who underwent fertility-sparing surgery (FSS).
Methods: A propensity score matching algorithm was performed between the BEP and PC groups. The χ² test and the Kaplan-Meier method were used to compare the fertility outcome, disease-free survival (DFS) and overall survival (OS). The Cox proportional hazards regression analysis was used to identify risk factor of DFS.
Results: We included 213 patients, 185 (86.9%) underwent BEP chemotherapy, and 28 (13.1%) underwent PC chemotherapy. The median age was 22 years (range, 8-44 years), and the median follow-up period was 63 months (range, 2-191 months). Fifty-one (29.3%) patients had a pregnancy plan, and 35 (85.4%) delivered successfully. In the before and after propensity score matching cohorts, there were no significant differences in spontaneous abortion, selective termination of pregnancy, during-pregnancy status, and live birth between the BEP and PC groups (p>0.05). Fourteen (6.6%) patients experienced recurrence, including 11 (5.9%) in the BEP group and 3 (10.7%) in the PC group. Four (1.9%) patients in the BEP group died. Kaplan-Meier analysis revealed no significant differences in DFS (p=0.328) and OS (p=0.446) between the BEP and PC groups, and the same survival results were observed in the after matching cohort.
Conclusion: The PC regimen is as safe as the BEP regimen for MOGCT patients with fertility preservation treatment, and no differences were observed in fertility and clinical prognosis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995871 | PMC |
| http://dx.doi.org/10.3802/jgo.2023.34.e12 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Shedding light on biochemical changes in single neuron-like pheochromocytoma cells following exposure to synchrotron sourced terahertz radiation using synchrotron source Fourier transform infrared microspectroscopy.
J Synchrotron Radiat
January 2025
School of Science, RMIT University, 2476, Melbourne, Victoria 3001, Australia.
Synchrotron sourced Fourier transform infrared (SS FTIR) microspectroscopy was employed to investigate the biological effects on the neuron-like pheochromocytoma (PC 12) cells after exposure to synchrotron sourced terahertz (SS THz) radiation. Over 10 min of exposure, the PC 12 cells received a total energy of 600 J m, with a total incident power density of ∼1.0 W m (0.
View Article and Find Full Text PDFFrench AFU Cancer Committee Guidelines - Update 2024-2026: Testicular germ cell cancer.
Fr J Urol
November 2024
Comité de Cancérologie de l'Association Française d'Urologie, groupe organes génitaux externes, Maison de l'Urologie, 11, rue Viète, 75017 Paris, France; Sorbonne University, GRC 5 Predictive Onco-Uro, AP-HP, Urology, Pitié-Salpêtrière Hospital, 75013 Paris, France.
Article Synopsis
- The objective of the review is to update guidelines for managing testicular germ cell tumors (TGT) based on recent literature from 2022.
- Initial diagnosis involves clinical exam, serum marker levels (AFP, hCG, LDH), and imaging techniques like ultrasound and CT scans; treatment starts with inguinal orchiectomy which helps in defining the tumor stage and treatment approach.
- For specific stages of the tumors, treatment strategies vary, including surveillance for stage I seminomas, risk-adapted options for stage I non-seminomatous tumors, and chemotherapy for metastatic cases, with additional measures like radiotherapy for certain seminoma stages.
Gender Differences in a Real-World Registry Examining Coronary Lithotripsy for Calcified Lesions.
Am J Cardiol
November 2024
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:
Article Synopsis
- * A total of 454 patients were included, with more men than women, and women showed higher rates of acute coronary syndrome and aorto-ostial lesions.
- * Results indicated that despite differences in clinical presentation, the safety and efficacy outcomes of IVL were comparable between men and women, demonstrating its effectiveness across genders.
Secondary Transcriptomic Analysis of Triple-Negative Breast Cancer Reveals Reliable Universal and Subtype-Specific Mechanistic Markers.
Cancers (Basel)
October 2024
Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA.
: Breast cancer is diagnosed in 2.3 million women each year and kills 685,000 (~30% of patients) worldwide. The prognosis for many breast cancer subtypes has improved due to treatments targeting the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).
View Article and Find Full Text PDFContact between leaked cement and adjacent vertebral endplate induces a greater risk of adjacent vertebral fracture with vertebral bone cement augmentation biomechanically.
Spine J
September 2024
Department of Orthopedics, Luzhou Key Laboratory of Orthopedic Disorders, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000, Sichuan Province, PR China. Electronic address:
Background Context: Adjacent vertebral fracture (AVF) is a frequently observed complication after percutaneous vertebroplasty in patients with osteoporotic vertebral compressive fracture (OVCF). Studies have demonstrated that intervertebral cement leakage (ICL) can increase the incidence of AVF, but others have reached opposite conclusions. The stress concentration initially increases the risk of AVF, and dispersive concentrated stress is the main biomechanical function of the intervertebral disc (IVD).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!