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Mechanobiology of cancer cell responsiveness to chemotherapy and immunotherapy: Mechanistic insights and biomaterial platforms. | LitMetric

Mechanobiology of cancer cell responsiveness to chemotherapy and immunotherapy: Mechanistic insights and biomaterial platforms.

Adv Drug Deliv Rev

NSF Science and Technology Center for Engineering Mechanobiology, Washington University, St. Louis, MO, USA; Department of Biomedical Engineering, School of Science and Engineering, Saint Louis University, St. Louis, MO, USA. Electronic address:

Published: May 2023

AI Article Synopsis

  • Mechanical forces play a crucial role in how cancer treatments like chemotherapy and immunotherapy interact with cells and tissues, influencing their effectiveness.
  • Electrostatic forces are key for binding, but mechanical factors also impact the ability of drugs and immune cells to reach targets and interact with their environment.
  • The review discusses the current understanding of mechanobiology's role in drug and immunotherapy resistance, as well as the in vitro systems used to study these effects.

Article Abstract

Mechanical forces are central to how cancer treatments such as chemotherapeutics and immunotherapies interact with cells and tissues. At the simplest level, electrostatic forces underlie the binding events that are critical to therapeutic function. However, a growing body of literature points to mechanical factors that also affect whether a drug or an immune cell can reach a target, and to interactions between a cell and its environment affecting therapeutic efficacy. These factors affect cell processes ranging from cytoskeletal and extracellular matrix remodeling to transduction of signals by the nucleus to metastasis of cells. This review presents and critiques the state of the art of our understanding of how mechanobiology impacts drug and immunotherapy resistance and responsiveness, and of the in vitro systems that have been of value in the discovery of these effects.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133187PMC
http://dx.doi.org/10.1016/j.addr.2023.114771DOI Listing

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