Rejuvenating muscle stem cells with the glutathione system.

Cell Metab

DAHFMO-Unit of Histology and Medical Embryology, Sapienza University of Rome, Laboratory affiliated with Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Via A. Scarpa, 14 Rome 00161, Italy. Electronic address:

Published: March 2023

Aging results from the combination of complex processes still largely undefined. In this issue, Benjamin et al. use multiomic analysis to reveal a causative role of altered glutathione (GSH) synthesis and metabolism in age-dependent muscle stem cell (MuSC) dysfunction, casting light on novel mechanisms regulating stem cell function and on therapeutic approaches to improve defective regeneration in the aged muscle.

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Source
http://dx.doi.org/10.1016/j.cmet.2023.02.009DOI Listing

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