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Endoscopic findings for predicting gastric acid secretion status.
Dig Endosc
July 2015
Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Background And Aim: Gastric acidic abnormalities are related to various types of diseases in Helicobacter pylori (H. pylori) infection status. However, no studies have shown correlations between many tiny endoscopic findings and the acid secretion level simultaneously.
View Article and Find Full Text PDFIdentification of a high-risk group for low-dose aspirin-induced gastropathy by measuring serum pepsinogen in H. pylori-infected subjects.
J Gastroenterol
March 2015
Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aobaku, Sendai, 980-8574, Japan,
Background: We recently demonstrated in humans that the extent of low-dose aspirin (LDA)-induced gastropathy was directly related to the individual gastric acid secretion level. We also established reliable cutoff serum pepsinogen (PG) values to predict gastric acid secretion status. In this study, we investigated the clinical usefulness of measuring the serum pepsinogen values for identifying a high-risk group for gastric mucosal injury among chronic LDA users.
View Article and Find Full Text PDFThe intriguing relationship of Helicobacter pylori infection and acid secretion in peptic ulcer disease and gastric cancer.
Dig Dis
April 2012
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany.
Helicobacter pylori infection induces chronic inflammation of the gastric mucosa and thus profoundly affects gastric physiology. In the acute phase of infection, gastric acid secretion is transiently impaired. The morphological damage of the gastric mucosa, changes in gastric hormone release, and disruption of neural pathways all contribute to influence gastric acid secretion in a distinct manner.
View Article and Find Full Text PDFWhy is the coexistence of gastric cancer and duodenal ulcer rare? Examination of factors related to both gastric cancer and duodenal ulcer.
Gastric Cancer
March 2011
Fourth Department of Surgery, Tokyo Medical University Ibaraki Medical Center, Inashiki, Ibaraki, 300-0395, Japan.
The coexistence of gastric cancer with duodenal ulcer has been found empirically to be rare, but why it is rare is difficult to explain satisfactorily. To elucidate this question, we carried out a literature review of the subject. The frequency with which the two diseases coexist is 0.
View Article and Find Full Text PDFGastric secretion.
Curr Opin Gastroenterol
November 2002
Department of Medicine, Division of Gastroenterology, Medical College of Virginia and McGuire VAMC Richmond, Virginia 23249, USA.
Overlapping neural, hormonal, and paracrine pathways finely regulate gastric acid secretion. In rats and guinea pigs, most of the intrinsic neural innervation to the gastric mucosa originates in the myenteric plexus. In contrast, human stomachs have a clearly defined submucosal plexus that contains a variety of transmitters including nitric oxide, vasoactive intestinal peptide (VIP), gastrin-releasing peptide (GRP), substance P, and calcitonin gene-related peptide (CGRP).
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