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Development and utilization of expressing green fluorescent protein to study spirochete-host interactions and antibody-mediated clearance: expanding the toolbox for syphilis research.
mBio
January 2025
Department of Medicine, University of Connecticut Health, Farmington, Connecticut, USA.
Article Synopsis
- Syphilis, caused by a spirochetal pathogen, can lead to serious health complications if untreated, necessitating new strategies to understand its complex pathogenesis.
- This study engineered a strain of the syphilis bacteria that expresses green fluorescent protein (GFP), allowing researchers to visualize its interactions with host cells and evaluate its infectivity in a rabbit model.
- The findings emphasize the role of specific antibody responses in targeting the bacteria's outer membrane, highlighting potential targets for protective immunity and paving the way for future research on spirochetal-host interactions.
Diagnosis and management of rectal syphilis-case report.
J Surg Case Rep
November 2024
Cambridge Colorectal Unit, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK.
The incidence and prevalence of syphilis are rising worldwide. Rectal syphilis is a rare condition with few reported cases in the literature and therefore often missed from differential diagnosis of atypical anorectal ulceration. We report a case of a 64-year-old male who presented with change in the bowel habit and a palpable rectal mass on examination.
View Article and Find Full Text PDFThe Great Imitator: The Many Faces of Syphilitic Skin Presentations.
Cureus
April 2024
Genitourinary Medicine, London North West University Healthcare National Health Service (NHS) Trust, London, GBR.
We report the case of a 22-year-old heterosexual man presenting with a pruritic rash to the sexual health clinic. He was initially suspected of having a fungal rash by his general practitioner (GP) and treated with antifungals unsuccessfully. Subsequent testing revealed an active infection with .
View Article and Find Full Text PDF[Solitary ulcer of unknown etiology on the glans penis].
Urologie
March 2023
Abteilung für Dermatologie und Venerologie, Medizinische Universität Graz, Graz, Österreich.
Ulcerations of the prepuce or foreskin of the penis are rare in the day-to-day life of a urologist. The most common differential diagnosis is invasive penile cancer, which is why other diagnoses are often overshadowed. We report a case of a syphilitic lesion which was initially misdiagnosed as penile cancer.
View Article and Find Full Text PDFHard bilateral syphilitic testes with vasculitis: a case report and literature review.
BMC Urol
September 2021
Department of Urology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo, 142-8555, Japan.
Background: We report the case of a patient with syphilitic testicular gumma and vasculitis with adrenal failure due to chronic steroid use.
Case Presentation: A 63-year-old male presented with hard right eye swelling and very firm bilateral testes on palpation, which he had for 2 years. Testicular tumor markers were negative; syphilis test was positive.
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