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Facilitating and restraining virus infection using cell-attachable soluble viral receptors.
Proc Natl Acad Sci U S A
November 2024
Thrombosis and Hemostasis Program, Versiti Blood Research Institute, Milwaukee, WI 53226.
Article Synopsis
- SARS-CoV-2 infects host cells by using its spike protein's receptor binding domain (RBD) to bind to the ACE2 receptor, which is crucial for the virus's entry into cells.
- The ACE2 receptor consists of several domains, with the peptidase domain (PD) being essential for its function as a viral receptor; however, the receptor needs to be close to the cell membrane for effective infection.
- Researchers found that engineered proteins targeting the RBD can influence whether cells are susceptible or resistant to the virus, indicating potential paths for antiviral therapies.
CSF1-dependent macrophage support matrisome and epithelial stress-induced keratin remodeling in Eosinophilic esophagitis.
Mucosal Immunol
September 2024
Allergy, Inflammation & Remodeling Research Laboratory, Kathleen Lonsdale Institute for Human Health Research, Department of Biology, National University of Ireland Maynooth, Co. Kildare, Ireland; Gastrointestinal Eosinophilic Diseases Program, Digestive Health Institute, Children's Hospital Colorado, Department of Pediatrics, University of Colorado School of Medicine, CO, USA. Electronic address:
Atopic diseases such as Eosinophilic Esophagitis (EoE) often progress into fibrosis (FS-EoE), compromising organ function with limited targeted treatment options. Mechanistic understanding of FS-EoE progression is confounded by the lack of preclinical models and the heavy focus of research on eosinophils themselves. We found that macrophage accumulation precedes esophageal fibrosis in FS-EoE patients.
View Article and Find Full Text PDFApplication of Palliative Hemostatic Radiotherapy in Canine Unresectable Oral Melanoma: A Case Report.
Animals (Basel)
June 2024
Department of Veterinary Medical Imaging, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.
A 9-year-old castrated male Schnauzer dog, weighing 11.6 kg, presented with a persistent hemorrhagic oral mass. An oral examination revealed a right maxillary oral mass characterized by continuous bleeding, halitosis, and severe pain.
View Article and Find Full Text PDFNovel tubing connectors reduce ECMO circuit thrombosis.
Int J Artif Organs
May 2024
Georgia Institute of Technology, Atlanta, GA, USA.
Background: Thrombosis within extracorporeal membrane oxygenation (ECMO) circuits is a common complication that dominates clinical management of patients receiving mechanical circulatory support. Prior studies have identified that over 80% of circuit thrombosis can be attributed to tubing-connector junctions.
Methods: A novel connector was designed that reduces local regions of flow stagnation at the tubing-connector junction to eliminate a primary source of ECMO circuit thrombi.
Aptameric hirudins as selective and reversible EXosite-ACTive site (EXACT) inhibitors.
Nat Commun
May 2024
Department of Surgery, Duke University, Durham, NC, USA.
Potent and selective inhibition of the structurally homologous proteases of coagulation poses challenges for drug development. Hematophagous organisms frequently accomplish this by fashioning peptide inhibitors combining exosite and active site binding motifs. Inspired by this biological strategy, we create several EXACT inhibitors targeting thrombin and factor Xa de novo by linking EXosite-binding aptamers with small molecule ACTive site inhibitors.
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