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Kawasaki disease involving both the nervous system and cardiovascular system: a case report and literature review.
Front Pediatr
December 2024
Department of Rheumatology and Immunology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Background: Kawasaki disease (KD), an acute self-limiting vasculitis, is the main cause of acquired heart disease. Timely diagnosis and treatment can mitigate the occurrence of complications and improve patient prognosis. Facial nerve paralysis (FNP) and ptosis are rare complications of KD and are rarely reported, but FNP is considered a high risk factor for coronary aneurysms.
View Article and Find Full Text PDFFulminant eosinophilic myocarditis and refractory ventricular arrhythmias requiring mechanical circulatory support: a case report.
Eur Heart J Case Rep
October 2024
Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.
Background: Fulminant eosinophilic myocarditis (EM) is a rare and often fatal condition that may present atypically and be complicated by ventricular arrhythmias. Treatment involves high-dose corticosteroids to suppress eosinophilia, as well as increasing use of mepolizumab, an anti-interleukin-5 antibody with evidence for long-term efficacy and safety.
Case Summary: A 38-year-old woman presented to the emergency department with neck pain and fatigue, and after extensive investigation was diagnosed with EM secondary to idiopathic hypereosinophilic syndrome.
Case report: Granulomatosis with polyangiitis patient presented with a mass in the aortic root.
Front Immunol
December 2024
Department of Ultrasound, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Granulomatosis with polyangiitis (GPA) is an autoimmune inflammatory disease that affects small- and medium-sized blood vessels in the body, representing a rare entity. Cardiac involvement was identified as an independent risk factor for death in GPA patients, yet it has not been systematically elucidated in previous literature. Cardiac lesions in patients with GPA can manifest in various ways, such as pericarditis, myocarditis, coronary vasculitis, valvular abnormalities, conduction system abnormalities, and heart failure.
View Article and Find Full Text PDFSequential delivery of cardioactive drugs via microcapped microneedle patches for improved heart function in post myocardial infarction rats.
Acta Biomater
January 2025
Department of Cardiovascular Medicine, Physiology and Biomedical Engineering, Center for Regenerative Medicine, Mayo Clinic Arizona, Scottsdale, AZ, 85259, USA. Electronic address:
Article Synopsis
- After a heart attack, the heart experiences negative changes like inflammation and fibrosis, which can lead to worsening heart function.
- The study focuses on a new microneedle patch that can release multiple medications in a timed sequence to target these changes effectively.
- Testing on rats showed that this patch improved heart health by reducing inflammation and enhancing function compared to a control patch, suggesting it's a promising approach for post-heart attack treatment.
Rhinovirus infection presenting with acute myocarditis with complete heart block in a child: a case report.
Cardiol Young
December 2024
Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chaing Mai, Thailand.
This report outlines a 9-year-old Thai boy with acute myocarditis due to rhinovirus infection, manifesting complete heart block. Despite aggressive treatment, including pulse methylprednisolone and temporary pacing, his condition remained unstable. He gradually improved over five days in the paediatric cardiac ICU and continued recovery over six months.
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