AI Article Synopsis
- Several new acridinium esters, modified with different phenoxycarbonyl groups and succinimidyloxycarbonyl groups, were synthesized and tested for light emission characteristics.
- The 2,5-dimethylphenyl derivatives produce a slow light glow when exposed to alkaline hydrogen peroxide, contrasted by the rapid flash emitted by the 2,6-dinitrophenyl and 2,6-bis(trifluoromethyl)phenyl versions.
- The type of substituent at the 10 position also plays a significant role in determining the hydrolytic stability of these compounds.
Article Abstract
Several new acridinium esters 2-9 having their central acridinium ring bearing a 9-(2,5-dimethylphenoxycarbonyl), 9-(2,6-bis(trifluoromethyl)phenoxycarbonyl) or 9-(2,6-dinitrophenoxycarbonyl) group, and a 10-methyl, 10-(3-(succinimidyloxycarbonyl)propyl), 10-(5-(succinimidyloxycarbonyl)pentyl), or 10-(10-(succinimidyloxycarbonyl)decyl) group, have been synthesized and their chemiluminescent properties have been tested. The 2,5-dimethylphenyl acridinium esters emit light slowly (glow) when treated with alkaline hydrogen peroxide, while the 2,6-dinitrophenyl and 2,6-bis(trifluoromethyl)phenyl esters emit light rapidly (flash). The substituent at the 10 position affects the hydrolytic stabilities of the compounds.
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| http://dx.doi.org/10.1002/bio.4474 | DOI Listing |
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