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Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing.
J Nanobiotechnology
January 2025
Department of Biobmedical Engineering and Technology, Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
The challenges associated with prolonged healing or non-healing of chronic diabetic wounds contribute significantly to the increased incidence of lower limb amputation. A pivotal factor in the impediment of healing is the reduced production of endogenous nitric oxide (NO) due to the hyperglycemic microenvironment typical of chronic diabetes. While both endogenous and exogenous NO have been shown to promote the healing process of diabetic wounds, the direct application of NO in wound management is limited due to its gaseous nature and the risk of explosive release.
View Article and Find Full Text PDFConcomitant motor responses facilitate the acquisition of multiple prior distributions in human coincidence timing.
Proc Biol Sci
January 2025
Graduate School of Integrated Science and Technology, Shizuoka University, Hamamatsu 432-8011, Japan.
The brain optimizes timing behaviour by acquiring a prior distribution of target timing and integrating it with sensory inputs. Real events have distinct temporal statistics (e.g.
View Article and Find Full Text PDFBioinspired Conductivity-Enhanced, Self-Healing, and Renewable Silk Fibroin Hydrogel for Wearable Sensors with High Sensitivity.
ACS Appl Mater Interfaces
January 2025
Hebei Provincial Key Laboratory of Photoelectric Control on Surface and Interface, and College of Science, Hebei University of Science and Technology, Yuxiang Road 26, Shijiazhuang 050080, PR China.
The development of silk fibroin-based hydrogels with excellent biocompatibility, aqueous processability, and facile controllability in structure is indeed an exciting advancement for biological research and strain sensor applications. However, silk fibroin-based hydrogel strain sensors that combine high conductivity, high stretchability, reusability, and high selectivity are still desired. Herein, we report a simple method for preparing double-network hydrogels including silk fibroin and poly(acrylic acid) sodium-polyacrylate (PAA-PAAS) networks.
View Article and Find Full Text PDFAltered cortical activation patterns in post-stroke patients during walking with two-channel functional electrical stimulation: a functional near-infrared spectroscopy observational study.
Front Neurol
January 2025
Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Restoration of independent walking ability is the primary objective of stroke rehabilitation; however, not all patients achieve this goal due to diverse impairments in the paretic lower limb and compensatory mechanisms that lead to an asymmetrical and mechanically inefficient gait. This investigation aimed to examine alterations in cortical activation in post-stroke patients while walking with a wearable two-channel functional electrical stimulation (FES) in comparison to walking without FES. This observational study was conducted to discern distinct activation patterns in 19 stroke patients during sessions with and without FES, while using functional near-infrared spectroscopy (fNIRS) to monitor changes in blood oxygen levels.
View Article and Find Full Text PDFBackground: The thin descending limb (DTL) of the loop of Henle is crucial for urine concentration, as it facilitates passive water reabsorption. Despite its importance, little is known about how DTL cells form during kidney development. Single-cell RNA sequencing (scRNA-seq) studies have not definitively identified DTL cells in the developing mouse kidney.
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