AI Article Synopsis
- This study reports on the use of gamma-irradiated sterile cornea (GISC) as a graft in deep lamellar keratoplasty (DALK) for a patient with keratoconus.
- A 33-year-old male experienced complications such as a persistent epithelial defect and sterile keratolysis after the procedure, requiring further surgeries.
- The report highlights this rare complication, encourages surgeons to consider graft replacement early, and suggests creating a registry to monitor complications associated with GISC in eye surgeries.
Article Abstract
Purpose: The purpose of this study was to report the outcomes of using gamma-irradiated sterile cornea (GISC) as a deep lamellar keratoplasty (DALK) graft in a patient with keratoconus.
Methods: This is a case report.
Results: A 33-year-old male patient diagnosed with keratoconus underwent DALK using a GISC and developed a persistent epithelial defect which eventually led to sterile keratolysis necessitating further surgical interventions. Management and slitlamp photography, anterior segment optical coherence tomography (AS-OCT), and histopathological examination of the explanted graft are described in detail.
Conclusions: This is the first reported case of sterile keratolysis after the use of GISC lenticule in DALK in a healthy patient with keratoconus. The underlying pathophysiology is not clearly understood, and some theories have been proposed in this report. Surgeons need to be aware of this rare complication and are encouraged to have a low threshold for graft replacement to ensure good clinical and visual outcomes. Developing a prospective complication registry to document complications after the use of GISC lenticules in ophthalmic surgery is recommended.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392883 | PMC |
| http://dx.doi.org/10.1097/ICO.0000000000003271 | DOI Listing |
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