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A Functional Polymorphism in IL-1B Is Associated With Immune Reconstitution Inflammatory Syndrome of Chronic Disseminated Candidiasis. | LitMetric
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A Functional Polymorphism in IL-1B Is Associated With Immune Reconstitution Inflammatory Syndrome of Chronic Disseminated Candidiasis.

Blandine Rammaert Pierre-Yves Bochud Anne-Sophie Brunel Agnieszka Wojtowicz Sophie Candon Maria Pilar Gallego Hernanz Olivier Lortholary

Open Forum Infect Dis

Université de Paris Cité, APHP, Service des Maladies Infectieuses et Tropicales, Hôpital Necker-Enfants Malades, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, Paris, France.

Published: March 2023

We investigated single nucleotide polymorphisms (SNPs) possibly involved in immune reconstitution inflammatory syndrome of chronic disseminated candidiasis (IRIS-CDC) through a candidate gene approach and a prospective matched-control study. We found that an SNP located in interleukin-1B at rs1143627 was significantly associated with the risk of developing IRIS-CDC.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984983PMC
http://dx.doi.org/10.1093/ofid/ofad078DOI Listing

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