AI Article Synopsis
- Inhibin (INH) is a glycoprotein hormone produced by the gonads that regulates the production of follicle-stimulating hormone (FSH), which is crucial for reproductive processes like follicle development and ovulation.
- INH significantly impacts reproductive capacity in animals, influencing factors such as litter size and egg production through its role in processes like corpus luteum formation and steroid hormone synthesis.
- Current theories on how INH inhibits FSH production include its effects on adenylate cyclase activity, FSH receptor expression, and its competition with activin, highlighting the complexity of INH's mechanisms in the reproductive system.
Article Abstract
Inhibin (INH) is a glycoprotein hormone secreted by the gonads that inhibit the synthesis and secretion of follicle-stimulating hormone (FSH). Increasing evidence indicates that INH plays a significant role in the development of the reproductive system including follicle development, ovulation rate, corpus luteum formation and ablation, steroid hormone synthesis and spermatogenesis, subsequently affecting the reproductive capacity of animals such as litter size and egg production. There are currently three main views on how INH inhibits FSH synthesis and secretion: influencing the activity of adenylate cyclase, the expression of follicle-stimulating hormone receptor or gonadotropin-releasing hormone receptor, and the competition system of inhibin-activin. This review discusses the current findings on the structure, function, and mechanism of action of INH in the reproductive system of animals.
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| http://dx.doi.org/10.1016/j.theriogenology.2023.02.016 | DOI Listing |
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