Evaluation of the inflammatory parameters for predicting stent thrombosis.

Objectives: Recent research demonstrated that classic inflammatory mediators were responsible for the development of stent thrombosis. We aimed to examine the relationship between predictors such as basophils, mean platelet volume (MPV), and vitamin D, which represented allergic, inflammatory, and anti-inflammatory states, and stent thrombosis after percutaneous coronary intervention.

Methods: In this observational case-control study, patients (n: 87) with ST-elevated myocardial infarction (STEMI) with stent thrombosis formed group 1, and (n = 90) with STEMI without stent thrombosis formed group 2. 25-OH vitamin-D and other laboratory values were obtained at the time of admission to the emergency room.

Results: In comparison to group 2, MPV was higher in group 1(9.05 ± 0.89 vs 8.17 ± 1.37 fL, respectively; p = 0.002). Group 2 had a higher basophil count than group 1(0.03 ± 0.05 vs 0.07 ± 0.080; p = 0.001). In comparison to group 2, group 1 had a greater vitamin-D level (p = 0.014). The MPV and basophil count were found as predictors for stent thrombosis in the multivariable logistic analyses. When MPV increased by one unit, the risk of stent thrombosis increased 1.69-times (95% CI: 1.038-3.023). Basophil counts below 0.02 increased the risk of stent thrombosis 12.74-times (95% CI: 4.22-36.00).

Conclusion: Increased MPV and basophil depletion might be predictors for coronary stent thrombosis following percutaneous coronary intervention (Tab. 4, Fig. 2, Ref. 25). Text in PDF www.elis.sk Keywords: MPV; basophil; vitamin D; stent thrombosis.