AI Article Synopsis
- The link between androgens and liver cancer has been recognized since 1975, but documented cases in patients using androgens are rare.
- This text presents three cases of patients who developed liver (HCC) and bile duct cancers while undergoing anabolic androgenic steroid (AAS) therapy and testosterone supplementation.
- It also reviews existing literature on how androgens may contribute to the malignant transformation of liver and bile duct tumors.
Article Abstract
Although the relationship between androgens and hepatocellular tumor development has been noted since 1975, cases involving hepatocellular carcinoma (HCC) or cholangiocarcinoma development in patients on chronic androgen therapy or anabolic androgenic steroid (AAS) use are few, and far between. We present three cases of patients who developed hepatic and bile duct malignancies in the setting of AAS use and testosterone supplementation, arising from a single tertiary referral center. Additionally, we review the literature for the mechanisms behind the possible androgen-mediated malignant transformation of these liver and bile duct tumors.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975287 | PMC |
| http://dx.doi.org/10.7759/cureus.34357 | DOI Listing |
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