Background: The question about the significance of opium consumption as a coronary artery disease (CAD) risk factor still remains open. The present study aimed to evaluate the association between opium consumption and long term outcomes of coronary artery bypass grafting (CABG) in patients without tandard odifiable CAD isk actors (SMuRFs; hypertension, diabetes, dyslipidemia, and smoking).
Methods: In this registry-based design, we included 23,688 patients with CAD who underwent isolated CABG between January 2006 to December 2016. Outcomes were compared in two groups; with and without SMuRF. The main outcomes were all-cause mortality, fatal and nonfatal cerebrovascular events (MACCE). Inverse probability weighting (IPW) adjusted Cox's proportional hazards (PH) model was used to evaluate the effect of opium on post-op outcomes.
Results: During 133,593 person-years of follow-up, opium consumption was associated with increased risk of mortality in both patients with and without SMuRFs (weighted Hazard Ratio (HR)s: 1.248 [1.009, 1.574] and 1.410 [1.008, 2.038], respectively). There was no association between opium consumption and fatal and non-fatal MACCE in patients without SMuRF (HR = 1.027 [0.762-1.383], HR 0.700 [0.438-1.118]). Opium consumption was associated with earlier age of CABG in both groups; 2.77 (1.68, 3.85) years in SMuRF-less and 1.70 (1.11, 2.38) years in patients with SMuRFs.
Conclusion: Opium users not only undergo CABG at younger ages but also have a higher rate of mortality regardless of the presence of traditional CAD risk factors. Conversely, the risk of MACCE is only higher in patients with at least one modifiable CAD risk factor.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982127 | PMC |
| http://dx.doi.org/10.3389/fsurg.2023.1047807 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Paternal addiction to cigarettes, alcohol, and opium and the psychological distress of their youths in southeast Iran.
Sci Rep
December 2024
Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Previous studies have reported inconsistent findings regarding paternal addiction to cigarettes, alcohol, and opium with psychological distress in youths. This study examined the association between paternal addiction to cigarettes, alcohol, and opium and the psychological distress of youths in southeast Iran. This cross-sectional study was conducted on 895 youths (aged 15-35) from the baseline phase of the Rafsanjan Youth Cohort Study (RYCS) whose fathers also participated in the Rafsanjan Cohort Study (RCS).
View Article and Find Full Text PDFInvestigating the relationship between opium use and coronary slow flow: a propensity score matched case-control study.
BMJ Open
December 2024
Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran (the Islamic Republic of).
Objectives: Recent studies have suggested a potential link between opium consumption and microvascular dysfunction in coronary arteries, which may contribute to the development of coronary slow-flow syndrome. This study aims to investigate the relationship between opium use and coronary slow-flow syndrome.
Design And Setting: This retrospective study analysed medical records of patients who underwent coronary angiography at the Tehran Heart Center from 2006 to 2020.
Office-based risk equation of Globorisk for prediction of ten-years cardiovascular risk among Iranian population: findings from Fasa PERSIAN cohort study.
BMC Med Res Methodol
October 2024
Research Center for Social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Iran.
Article Synopsis
- The study evaluates the 10-year cardiovascular disease (CVD) risk using the office-based Globorisk model, which doesn't require lab tests and relies on factors like age, sex, and lifestyle choices.
- The research involved 6810 individuals from the Fasa cohort study without previous CVD history, categorizing them into low, moderate, and high-risk groups based on their predicted risk.
- The results revealed demographic and lifestyle factors affecting CVD risk differently for men and women, underscoring the importance of addressing these factors in prevention strategies.
Prevalence and associated factors of ECG abnormality patterns indicative of cardiac channelopathies among adult general population of Tehran, Iran: a report from the Tehran Cohort Study (TeCS).
BMC Cardiovasc Disord
October 2024
Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- The study investigated ECG abnormalities related to cardiac channelopathies linked to sudden cardiac death among adults in Tehran, Iran, highlighting their under-recognition in the region.
- Out of 7,350 analyzed ECGs, long QT intervals were the most common abnormality found at 3.08%, with several factors influencing their prevalence, such as age and lifestyle choices.
- Overall, those with abnormal ECG patterns had a significantly higher all-cause mortality rate (6.3%) compared to those without such patterns (2.96%), indicating potential health risks.
Different Etiologies of Dilated Pancreatic Duct Based on Endoscopic Ultrasonography Findings.
Middle East J Dig Dis
July 2024
Commission for Academic Accreditation, Ministry of Education, Khalifa City, Abu Dhabi, UAE.
Article Synopsis
- The study investigates pancreatic duct (PD) dilation identified through endoscopic ultrasonography (EUS) and its potential links to various pancreatic and biliary diseases.
- Among 3,109 subjects, 599 had PD dilation; the most common diagnosis was pancreatic adenocarcinoma, found in 39.4% of cases, followed by sphincter of Oddi dysfunction.
- The findings suggest that PD dilation is a significant indicator of pancreatic neoplasms and other related conditions, highlighting its importance in clinical assessments even when the cause is not clear.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!